A skeletal muscle is composed of a variety of tissues Slide number: 2 Muscle Bone Tendon Fascia (covering muscle) Pg 294 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

A skeletal muscle is composed of a variety of tissues Slide number: 3 Muscle Bone Tendon Fascia (covering muscle) Epimysium Perimysium Endomysium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

A skeletal muscle is composed of a variety of tissues Slide number: 4 Muscle Bone Tendon Fascia (covering muscle) Fascicles Fascicle Axon of motor neuron Blood vessel Epimysium Perimysium Endomysium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

A skeletal muscle is composed of a variety of tissues Slide number: 5 Muscle Bone Tendon Fascia (covering muscle) Fascicles Fascicle Axon of motor neuron Blood vessel Muscle fibers (cells) Muscle fiber Sarcolemma Nucleus Sarcoplasmic reticulum Epimysium Perimysium Endomysium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

A skeletal muscle is composed of a variety of tissues Slide number: 6 Muscle Bone Tendon Fascia (covering muscle) Fascicles Fascicle Axon of motor neuron Blood vessel Muscle fibers (cells) Muscle fiber Sarcolemma Nucleus Sarcoplasmic reticulum Myofibrils Myofibril Epimysium Perimysium Endomysium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

A skeletal muscle is composed of a variety of tissues Slide number: 7 Muscle Bone Tendon Fascia (covering muscle) Fascicles Fascicle Axon of motor neuron Blood vessel Muscle fibers (cells) Muscle fiber Sarcolemma Nucleus Sarcoplasmic reticulum Myofibrils Myofibril Epimysium Perimysium Endomysium Thick and thin filaments Filaments Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.04 Pg. 171 Muscle Fiber

Packet, Pg. 10 Muscle Fiber Fascicle

1. 2. 3. 4. 6. 11. 12. 7. 10. 5. 9. 8.

Pg. 296 Skeletal muscle fiber Slide number: 2 A B Sarcoplasmic reticulum Myofibril Pg. 296 A B Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Skeletal muscle fiber Slide number: 3 Sarcomere A B Sarcoplasmic reticulum Myofibril Z line Sarcomere A B Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Skeletal muscle fiber Slide number: 4 A B Skeletal muscle fiber Sarcoplasmic reticulum Myofibril Z line Sarcomere Myosin (thick) filaments Actin (thin) A B Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Skeletal muscle fiber Slide number: 5 A B Skeletal muscle fiber Sarcoplasmic reticulum Myofibril Z line Sarcomere Myosin (thick) filaments Actin (thin) H zone M line I band A band A B Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.03 Pg. 296 H zone

Packet Pg. 12

1. 2. 3. 4. 6. 11. 12. 7. 10. 5. 9. 8.

H-zone

Pg. 306

Packet Pg. 11

Pg. 298 Fig. 8.05 Neuromuscular Junction

Packet Pg. 11

Packet Pg. 16

Pg. 297

1. 2. 3. 4. 6. 11. 12. 7. 10. 5. 9. 8.

A skeletal muscle is composed of a variety of tissues Slide number: 6 Muscle Bone Tendon Fascia (covering muscle) Fascicles Fascicle Axon of motor neuron Blood vessel Muscle fibers (cells) Muscle fiber Sarcolemma Nucleus Sarcoplasmic reticulum Myofibrils Myofibril Epimysium Perimysium Endomysium Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Pg. 296 Thick filaments Slide number: 2 Myosin molecule Actin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Thick filaments Slide number: 3 Cross-bridges Troponin Tropomyosin molecule Actin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Thick filaments Slide number: 4 Cross-bridges Troponin Tropomyosin Actin filament Myosin filament Myosin molecule Actin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 2 Pg. 300 Tropomyosin Troponin complex Actin filament Actin monomers ADP + P ADP + P Myosin filament Ca+2 Muscle contraction Release of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament: Ca+2 binds to troponin complex Tropomyosin pulled aside Binding sites on actin filament exposed Ca+2 Ca+2 Ca+2 ADP + P ADP + P 1 Exposed binding sites on actin allow the muscle contraction cycle to occur Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 9 Ca+2 Ca+2 Ca+2 ADP + P ADP + P 1 Exposed binding sites on actin allow the muscle contraction cycle to occur Contraction cycle ADP + P ADP + P ADP + P ADP + P 5 ATP splits, which provides power to “cock” the myosin cross-bridge 2 Cross-bridge binds actin to myosin ADP ADP ATP ATP ATP P P ATP ADP + P 4 New ATP binds to myosin, causing linkage to release 3 Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 8 ADP + P ADP + P Ca+2 Muscle relaxation Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable. ATP Ca+2 ADP + P ADP + P Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

When a skeletal muscle contracts Slide number: 2 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

When a skeletal muscle contracts Slide number: 3 A band Sacromere Z line Actin filaments Myosin 1 Relaxed Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

When a skeletal muscle contracts Slide number: 4 A band Sacromere Z line Actin filaments Myosin 1 Relaxed 2 Contracting Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

When a skeletal muscle contracts Slide number: 5 A band Sacromere Z line Actin filaments Myosin 1 Relaxed 2 Contracting 3 Fully contracted Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 1 Tropomyosin Troponin complex Actin filament Actin monomers ADP + P ADP + P Myosin filament Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 3 Contraction cycle Ca+2 ADP + P ADP + P ADP + P ADP + P 2 Cross-bridge binds actin to myosin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 4 Contraction cycle ADP + P ADP + P P ADP ADP + P 3 Cross-bridge pulls actin filament (power stroke), ADP and P released from myosin Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 5 Contraction cycle ATP 4 New ATP binds to myosin, causing linkage to release ATP P ADP Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 6 Contraction cycle ADP + P ADP + P 5 ATP splits, which provides power to “cock” the myosin cross-bridge ATP Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 7 Contraction cycle Ca+2 ADP + P ADP + P ADP + P ADP + P Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Sliding filament theory Slide number: 10 Tropomyosin Troponin complex Actin filament Actin monomers ADP + P ADP + P Myosin filament Ca+2 Ca+2 Muscle contraction Muscle relaxation Release of Ca+2 from sarcoplasmic reticulum exposes binding sites on thin filament: Active transport of Ca+2 into sarcoplasmic reticulum, which requires ATP, makes myosin binding sites unavailable. Ca+2 binds to troponin complex ATP Tropomyosin pulled aside Binding sites on actin filament exposed Ca+2 Ca+2 Ca+2 ADP + P ADP + P 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.