1. The Muscular System

2. The characteristics of muscle tissue enable it to perform some important functions, including:  Movement – both voluntary & involuntary  Maintaining posture  Supporting soft tissues within body cavities  Guarding entrances & exits of the body  Maintaining body temperature

3. For muscles to create a movement, they can only pull, not push Muscles in the body rarely work alone, & are usually arranged in groups surrounding a joint A muscle that contracts to create the desired action is known as an agonist or prime mover A muscle that opposes the action of the agonist, therefore undoing the desired action is an antagonist

4. Types of muscle tissue: Skeletal muscle tissue Associated with & attached to the skeleton Under our conscious (voluntary) control Microscopically the tissue appears striated Cells are long, cylindrical & multinucleate

5. Cardiac muscle tissue Makes up myocardium of heart Unconsciously (involuntarily) controlled Microscopically appears striated Cells are short, branching & have a single nucleus Cells connect to each other at intercalated discs

6. Smooth (visceral) muscle tissue Makes up walls of organs & blood vessels Tissue is non-striated & involuntary Cells are short, spindle-shaped & have a single nucleus Tissue is extremely extensible, while still retaining ability to contract

7. Skeletal Muscle Smooth Muscle Cardiac Muscle

8. Anatomy of skeletal muscles Skeletal muscle fiber (cell) Muscle Fascicle Surrounded by perimysium Surrounded by endomysium endomysium perimysium Skeletal muscle Surrounded by epimysium epimysium tendon

9. Organization of Skeletal Muscles

10. Microanatomy of a Muscle Fiber

11. Microanatomy of a Muscle Fiber (Cell) sarcolemma transverse (T) tubules sarcoplasmic reticulum terminal cisternae myofibril thin myofilament thick myofilament triad mitochondria nucleus

12. Muscle fiber myofibril Thin filamentsThick filaments Thin filament Myosin molecule sarcomere Z-line

13. Thin Myofilament (myosin binding site) Tropomyosin (blue) winds around action (pink). Troponin sits on Tropomysin

14. Thick myofilament (myosin molecule) ( has ATP & actin binding site) The Myosin head binds to actin during muscle contraction

15. Z line Thin myofilaments M line Thick myofilaments Z line Myofilaments of sarcomere

16. Sliding Filament Theory Myosin heads attach to actin molecules (at binding (active) site) Myosin “pulls” on actin, causing thin myofilaments to slide across thick myofilaments, towards the center of the sarcomere Sarcomere shortens As sarcomeres shorten, myofibril shortens. As myofibrils shorten, so does muscle fiber Once a muscle fiber begins to contract, it will contract maximally This is known as the “all or none” principle

17. Physiology of skeletal muscle contraction Skeletal muscles require stimulation from the nervous system in order to contract Motor neurons are the cells that cause muscle fibers to contract (motor neuron) cell body dendrites axon Synaptic terminals (synaptic end bulbs) telodendria

18. Synaptic terminal (end bulb) Neuromuscular junction Synaptic vessicles containing Ach Motor end plate of sarcolemma Synaptic cleft Neuromuscular junction

19. Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Figure 7-5 7 of 7 Resting sarcomere Myosin head Myosin reactivation Active-site exposure Cross bridge detachment Cross-bridge formation Pivoting of myosin head Troponin Actin Tropomyosin ADP P + P + P + Active site Sarcoplasm Ca 2+ ADP P + + P Ca 2+ ADP + P Ca 2+ ADP + P Ca 2+ ADP + P Ca 2+ ATP Ca 2+ ADP P + + P

20. Muscle Contraction Video