Creutzfeldt-Jakob Disease

Slides:

Advertisements

Similar presentations

Distinctive characteristics

Advertisements

Creutzfeldt-Jakob Disease Classic CJD occurs worldwide at 1-2 cases per million population per year In people over 50, the annual rate is about 3.4 per.

Prokaryotes and Viruses Chapter 21. Microorganisms  Single-celled organisms that are too small to be seen without a microscope  Bacteria are the smallest.

Life At Risk: Infectious Disease Chapter 18. Virus Noncellular infectious agent Consists of protein wrapped around a nucleic-acid core Cannot reproduce.

Microbiology- a clinical approach by Anthony Strelkauskas et al Chapter 8: Emerging and re-emerging infectious diseases.

Chronic Wasting Disease in Elk and Mule Deer What is “Chronic Wasting Disease” (CWD) A transmissible spongiform encephalopathy that effects the brain.

Are humans susceptible?

1 Transmissible Spongiform Encephalopathies. 2 Kuru Since the early 1900’s the Fore people of New Guinea have honored their dead by cooking and consuming.

Prions Fact or Science Fiction?. Stanley Prusiner, 1982 Born in Des Moines, Ia. Suggested that spongiform encephalopathies in animals and humans are caused.

L and D isomers of amino acids. Ionization state as a function of pH.

Prions Alicia Arguelles, Jerry Wang May 4, What are prions? proteinaceous infectious particle an infectious agent made only of protein, containing.

Mad Cow Disease. Effects of Mad Cow disease Mad cow disease, or bovine spongiform encephalopathy (BSE), is a fatal brain disorder that occurs in cattle.

© Elsevier, 2011.Principles of Molecular Virology Subviral Agents Satellites and viroids – parasites of parasites! Prions - infectious protein molecules.

Prion Diseases Microbes and Society Fall What is a Prion? Prion- small proteinaceous infectious particles which resist inactivation by procedures.

Viruses Chapter Nature of Viruses All viruses have same basic structure -Nucleic acid core surrounded by capsid Nucleic acid can be DNA or RNA;

Chapter 13 viruses. Structure of viruses Acellular Either have DNA or RNA Surrounded by a protein coat (capsid). Envelope – proteins, carbohydrates, lipids.

Holly Allen CREUTZFELDT-JAKOB DISEASE.  Human equivalent of mad cow disease  Rare, degenerative, fatal disease  Approximately 1 case per million per.

Prions: Proteins Gone Bad

Variant Creutzfeldt-Jakob Disease (vCJD). By Georgie Hill 10 Science 2 CJD Bacteria.

PRIONS Kalina Estrada TA: Yu-Chen Hwang Thursday, 7-8pm.

Chronic Wasting Disease in Elk and Mule Deer Charles Christenson Advanced Animal Science Instructor: Randall Cale Rugby,ND High School Dec

Maternal immunity. Acquired immunity Very small group ( < 20 birds??) Mortality may be high Natural selection (??)

Prion. Similar to Viruses Atypical Agents  Small  Filterable  Need host cells  No machinery for energy generation of protein synthesis.

Grace and Sienna Period 1. Mad cow disease is also known as bovine spongiform encephalopathy, or BSE. Mad Cow Disease is an illness in cows that affects.

Uncommon neurological conditions and possible advances in their management By Andrey Pashvykin.

The History of Chronic Wasting Disease Dr. Trent Bollinger, CCWHC One World, One Health Symposium Sept. 29, 2004.

LIFE CYCLES OF VIRUSES. VIRUSES CAN EXHIBIT TWO TYPES OF LIFE CYCLES. 1. THE LYTIC CYCLE 2. THE LYSOGENIC CYCLE SOME VIRUSES EXHIBIT ONLY THE LYTIC CYLE.

Kuru A PRION DISEASE.

Prions “Scrapie” “mad cow disease” Nobel Prize 1997

PD – Circuitry changes PD HD Normal. Causes of PD  Genetics  Several identified mutations associated with PD  LRRK2 mutations – some are autosomal.

MAD COW DISEASE Anna Hoffmann. What is it?  Mad cow disease, or bovine spongiform encephalopathy (BSE), is a transmissible, slowly progressive fatal.

Creutzfeldt-Jakob Disease Atif Chohan & Alex Brown.

DISEASE: Pathogen name that causes the disease: Student Name:

Viral Diseases Microbiology.

CLINICAL CORRELATIONS

Creutzfeldt-Jakob disease (transmissible spongiform encephalopathy)

Petra Jenišová Veronika Plačková Magdaléna Trojanová

MICROBIAL FOOD SAFETY A FOOD SYSTEMS APPROACH

Bovine Spongiform Encephalopathy Variant Creutzfeldt-Jakob disease

Alzheimer’s Disease 1 in 9 people in the US aged 65 and older

Rabies virus and Prion Dongli Pan

CHARCOT-MARIE-TOOTH (CMT)

Asperger’s syndrome (AS)

Zika Virus Pathogenic Viral Infection

GROUPS and TOPICS TKRKPO Dysfunction Junction

Down syndrome (DS) Trisomy 21 Not inherited Cell division error

Lyme Disease Pathogenic neurological disease

Cerebral Palsy (CP) Disorder of movement, muscle tone or posture that is caused by an insult to the immature, developing brain, most often before birth.

Epilepsy and Seizure CNS disorder due to activity imbalance

X-Linked Intellectual Disability (XLID, XLMR)

Chapter 19- Viruses.

Viruses Section 18-2.

Viruses, Prions, and Viroids

How do we study culture? The mystery of the Fore..

Course Schedule Day 1 Day 2 8:00 AM - 9:30 AM 9:30 AM - 9:45 AM

What is Epidemiology? Epidemiology is the study of patterns of health, illness and associated factors at the population level. Epidemiologists study the.

Multiple Sclerosis Rare disease < 200,000 cases per year

By Alagu Paramesh Veerappan And Grant Ellison

Infectious Disease.

Viruses Ch 18 Big Idea 3: Living systems store, retrieve, transmit, and respond to info essential to life processes.

Identify as virus, bacteria, protozoa, or parasite

Alzheimer’s Disease and Dementia

Prokaryotes and Viruses

Figure 2. Neuropathologic diagnosis of Creutzfeldt-Jakob disease (CJD) at postmortem Neuropathologic diagnosis of Creutzfeldt-Jakob disease (CJD) at postmortem.

Course Schedule Day 1 Day 2 8:00 AM - 9:30 AM 9:30 AM - 9:45 AM

VIRUSES And PRIONS.

Course Schedule Day 1 Day 2 8:00 AM - 9:30 AM 9:30 AM - 9:45 AM

What are Prions? A microscopic protein particle similar to a virus but lacking nucleic acid.

Fig. 2. Reportedly pathogenic PRNP variants: Mendelian, benign, and intermediate variants. Reportedly pathogenic PRNP variants: Mendelian, benign, and.

Presentation transcript:

Creutzfeldt-Jakob Disease Extremely Rare pathogenic neurologic disease Human form of transmissible spongiform encephalopathies Sporadic Majority Hereditary (PRNP mutation of PRP) Acquired or transmitted 1-2/1,000,000 annual cases Made famous by late 1980’s early 1990’s epidemic of Mad Cows Disease No treatments or cure

Team Workshop 1: What are the structures of IND24 and IND81?

Team Workshop 2: Use CHEMBL to find any compounds reported to bind PRP Team Workshop 2: Use CHEMBL to find any compounds reported to bind PRP? How do they relate to IND24 and IND81?

Team Workshop 3: Go to the RSCB and download the PRP structure Team Workshop 3: Go to the RSCB and download the PRP structure. Use either FINDSITE-COMB or eFINDSITE (please only 1 person from your group) to predict small molecules drugs binding to PRP? Propose a MOA for one of the predicted compounds and elect one member of your team to briefly explain your results.

Remember Before 12 PM of the next class day: go to b.socrative.com/student/login and complete the quiz