Epidermal Growth Factor Receptor-Related Tumor Markers and Clinical Outcomes with Erlotinib in Non-small Cell Lung Cancer: An Analysis of Patients from.

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Epidermal Growth Factor Receptor-Related Tumor Markers and Clinical Outcomes with Erlotinib in Non-small Cell Lung Cancer: An Analysis of Patients from German Centers in the TRUST Study Claus-Peter Schneider, MD, David Heigener, MD, Kathrin Schott-von-Römer, MD, Sylvia Gütz, MD, Eckart Laack, MD, Werner Digel, MD, Wolf-Rüdiger Guschall, MD, Andreas Franke, MD, Heinrich Bodenstein, MD, Claudia Schmidtgen, PhD, Martin Reck, MD, PhD Journal of Thoracic Oncology Volume 3, Issue 12, Pages 1446-1453 (December 2008) DOI: 10.1097/JTO.0b013e31818ddcaa Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Progression-free (A) and overall survival (B) during treatment with erlotinib. Journal of Thoracic Oncology 2008 3, 1446-1453DOI: (10.1097/JTO.0b013e31818ddcaa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Survival outcomes according to tumor marker status. Epidermal growth factor receptor (EGFR), fluorescence in situ hybridization (FISH) (A), EGFR mutation analysis (B) and KRAS mutation analysis (C). Journal of Thoracic Oncology 2008 3, 1446-1453DOI: (10.1097/JTO.0b013e31818ddcaa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Progression-free survival (PFS) (A) and overall survival (OS) (B) according to phosphorylated mitogen-activated protein kinase (pMAPK) status (immunohistochemistry). Journal of Thoracic Oncology 2008 3, 1446-1453DOI: (10.1097/JTO.0b013e31818ddcaa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Epidermal growth factor receptor (EGFR), immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) status in adenocarcinomas (A) and squamous cell carcinomas (B). Journal of Thoracic Oncology 2008 3, 1446-1453DOI: (10.1097/JTO.0b013e31818ddcaa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions