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Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure  Joel P. Womack,

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Presentation on theme: "Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure  Joel P. Womack,"— Presentation transcript:

1 Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure  Joel P. Womack, MD, Marileila Varella-Garcia, PhD, D. Ross Camidge, MD, PhD  Journal of Thoracic Oncology  Volume 10, Issue 12, Pages e115-e118 (December 2015) DOI: /JTO Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Reemergence of partial EGFR TKI sensitivity during time off EGFR TKI therapy (relaxation of specific selection pressure). PET/CT chest imaging. A, Progression of disease after 20 months on erlotinib therapy (right pleural effusion) (arrows). B, No metabolic evidence of malignancy after five cycles of chemotherapy (sunitinib±pemetrexed trial). C, Progression of disease after 16 cycles of sunitinib (arrows). D, Minor response to erlotinib rechallenge after 5 weeks on erlotinib. E, Progression of disease after 14 weeks of erlotinib rechallenge (arrows). CT, computed tomography; EGFR, epidermal growth factor receptor; PET, positron emission tomography; TKI, tyrosine kinase inhibitor. Journal of Thoracic Oncology  , e115-e118DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Waning MET expression in the absence of erlotinib selection pressure. fluorescent in situ hybridization analysis of malignant cells from pleural fluid. A, Widespread MET copy number gain (MET/CEP7 = 4.13) in the setting of progression of disease on erlotinib in March B, Waning of MET copies per cell after 10 months off erlotinib therapy in January Only tumor nuclei on the right exhibit MET gene clusters (arrows). Red = MET probe, green = CEP7 probe. Journal of Thoracic Oncology  , e115-e118DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

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