From: Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate.

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From: Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate Ann Intern Med. 2006;145(4):247-254. doi:10.7326/0003-4819-145-4-200608150-00004 Figure Legend: A. Four-variable Modification of Diet in Renal Disease (MDRD) Study equation. B. 6-variable MDRD Study equation. C. Cockcroft–Gault equation adjusted for body surface area. D. Cockcroft–Gault equation adjusted for body surface area and corrected for bias. Points indicate individual patients. Patients with differences between measured and estimated GFR greater than 60 mL/min per 1.73 m2 are not shown. The dashed horizontal line is the reference line. The solid black line is the smooth estimate of the mean difference, and the 2 dotted lines represent the 95% of the population of differences across the range of estimated GFR. Curves are drawn through the 2.5% to 97.5% of the range of GFR estimates. Values for R2 (95% CIs) are for the regression of measured GFR versus estimated GFR. Date of download: 1/23/2018 Copyright © American College of Physicians. All rights reserved.

From: Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate Ann Intern Med. 2006;145(4):247-254. doi:10.7326/0003-4819-145-4-200608150-00004 Figure Legend: For each curve, the sensitivity and specificity were computed for varying cutoff values for estimated glomerular filtration rate (GFR) to detect a measured GFR of less than 60 mL/min per 1.73 m2. AUC = area under the curve; MDRD = Modification of Diet in Renal Disease; NPV = negative predictive value; PPV = positive predictive value.* P < 0.001 for the comparison of the AUCs with the 4-variable MDRD Study equation. The AUCs for the Cockcroft–Gault equation with and without adjustment for bias are identical because these equations are equivalent except for a constant multiplier. Date of download: 1/23/2018 Copyright © American College of Physicians. All rights reserved.

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