Wei Zuo 1 ;Feng Yan 2, 3 ;Bo Zhang 1 ;Jiantao Li 1 ;Dan Mei 1 ;

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Wei Zuo 1 ;Feng Yan 2, 3 ;Bo Zhang 1 ;Jiantao Li 1 ;Dan Mei 1 ; Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases Wei Zuo 1 ;Feng Yan 2, 3 ;Bo Zhang 1 ;Jiantao Li 1 ;Dan Mei 1 ; 1 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences #cod#x00026; Peking Union Medical College, Beijing, China ; 2 Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China ; 3 Department of Neurobiology, Capital Medical University, Beijing, China ; Figure 4. Death receptor mediated apoptosis The extracellular Fas ligand first binds to a receptor, and then binds to FADD protein. This complex activates procaspase-8 into caspase-8. Then, caspase-8 activates caspase-3 and this effector caspase leads to DNA damage and cell death. What is more, Fas ligand such as TNF-#cod#x003B1;, can also induce NF-#cod#x003BA;B activation and transcription. EGb protects against apoptosis by decreasing the expression of FasLFasR and inhibiting NF-#cod#x003BA;B activation. Aging and Disease,null,8(6),812-826. Doi:10.14336/AD.2017.0615