Mersin University TURKEY

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Mersin University TURKEY Association between CARD15/NOD2 gene polymorphisms and Ulcerative colitis and Crohn’s disease in Turkish population Songül BUDAK DILER Niğde University TURKEY Ebru DERICI EKER Mersin University TURKEY Fikriye POLAT Kocaeli University TURKEY Serkan YARAS Mersin University TURKEY

Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory bowel diseases (IBD) which are similar to each other for their clinical features and epidemiology. Although pathogenesis of these diseases has not been well known yet, one of the most viable hypotheses is the genetic predisposition. Crohn’s disease

This study included 153 healthy controls and 107 patients (42 CD and 65 UC) with CD and UC. The P268S and M863V gene regions were amplified using polymerase chain reaction (PCR), detected by restriction fragment length polymorphism (RFLP). CARD15/NOD2 polymorphism in patients with Crohn’s Disease (CD) and Healthy Controls

Conflict of Interests: None CARD15/NOD2 polymorphism in patients with Ulcerative Colitis (UC) and Healthy Controls 212 bp and 160 bp were found in wild-type M863V in all subjects and no other mutant band of M863V was detected using PCR-RFLP. There are no association P268S and M863V polymorphisms between patients with CD and UC and the control groups in Turkish population. Conflict of Interests: None