Doina M. Racila, MD, Joel N. Kline, MD, MSc

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Presentation transcript:

Perspectives in asthma: Molecular use of microbial products in asthma prevention and treatment Doina M. Racila, MD, Joel N. Kline, MD, MSc Journal of Allergy and Clinical Immunology Volume 116, Issue 6, Pages 1202-1205 (December 2005) DOI: 10.1016/j.jaci.2005.08.050 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Microbes, parasites, and microbial products induce protection against asthma and atopic inflammation. Interactions with TLRs on innate immune cells, including DCs, alveolar macrophages, B cells, and others, are known to be an important link in these innate immune pathways that lead to enhanced TH1, suppressed TH2, and induced T-regulatory responses. Both TH1 and regulatory T lymphocyte (Treg) cells can suppress TH2 cells and their mediators. Journal of Allergy and Clinical Immunology 2005 116, 1202-1205DOI: (10.1016/j.jaci.2005.08.050) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions