Figure 1. A B C D E F Survival proability (%) Bone marrow blast count 20 40 60 80 100 Time since sample collection (years) 1 2 3 5 4 6 7 8 high intermediate low 5.0 5.5 6.0 6.5 7.0 7.5 8.0 Control <5% 5-10% 11-20% Bone marrow blast count Proliferation signature score C D CDKN1C (log2 expression levels) Proliferation signature score MKI67 (log2 expression levels) CDKN1C (log2 expression levels) E F CDKN1C (log2 expression levels) 2 4 6 8 10 Control <5% 5-10% 11-20% Bone marrow blast count Time since sample collection (years) 1 2 3 4 5 6 7 8 20 40 60 80 100 Survival probability (%) CDKN1C expression level intermediate low high

Figure 2. A B * C D E F * CD34+Ki67+ (%) CD34+KI67+ (%) 3 2 1 CD34+ 10 20 30 40 50 60 control < 5% 5-10% 11-20% CD34+Ki67+ (%) * Bone marrow blast count C D Relative CDKN1C expression CD34+ 1 P = 0.02 CD34- #1 #2 #3 CDKN1C β-actin CD34 + - 10 20 30 40 50 CD34- CD38high CDKN1C transcripts CD34+ CD38low E F 10 20 30 40 50 60 CD34+KI67+ (%) CDKN1C positive negative *

Figure 3. A B C Survival probability (%) P = 0.30 P = 0.002 P = 0.40 1 2 3 4 5 6 7 8 9 10 11 12 13 Time since sample collection (years) 20 40 60 80 100 Survival probability (%) P = 0.30 CDKN1C status positive negative P = 0.002 P = 0.40 A B C

A B Figure 4. Survival probability (%) P = 0.08 P = 0.008 1 2 3 4 5 6 7 8 9 10 11 12 13 Time since sample collection (years) 20 40 60 80 100 Survival probability (%) CDKN1C status positive negative P = 0.08 A P = 0.008 B