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Leukemic blasts express a “hypoxia signature

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1 Leukemic blasts express a “hypoxia signature
Leukemic blasts express a “hypoxia signature.” Bone marrow (BM, N = 3) and peripheral blood (PB, N = 12) samples from patients with AML (N = 15) and healthy subjects (PB, N = 2; BM, N = 2) were collected during routine diagnostic procedures and subjected to... Leukemic blasts express a “hypoxia signature.” Bone marrow (BM, N = 3) and peripheral blood (PB, N = 12) samples from patients with AML (N = 15) and healthy subjects (PB, N = 2; BM, N = 2) were collected during routine diagnostic procedures and subjected to Nanostring analysis. A, genes whose expression in AML samples was significantly different than that in normal samples. B, hypoxia signature index (calculated for each sample by averaging the relative expression of all genes with detectable levels) in samples from healthy donors and patients with AML. P value was calculated using unpaired t test with Welch correction. Juliana Benito et al. Clin Cancer Res 2016;22: ©2016 by American Association for Cancer Research

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