DIGESTION & ABSORPTION OF LIPIDS

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Presentation transcript:

DIGESTION & ABSORPTION OF LIPIDS

Major dietary lipids are TGL, cholesterol & phospholipids. Digestion of lipids is initiated in the stomach, catalysed by lingual lipase. pH RANGE 2.0-7.5(OPTIMUM 4 TO 4.5) IN THE STOMACH 30% OF TGL MAY BE DIGESTED

GASTRIC LIPASE is acid stable, optimum pH 5.4. secreted by Chief cells. The secretion is stimulated by GASTRIN. ACTION IS NEGLIGIBLE BECAUSE 1. NO EMULSIFAICATION OF FAT TAKE PLACE IN STOMCH 2. LOW pH IN STOMACH IS INFAVORABLE FOR THE ACTION OF GASTRIC LIPASE.

DIGESTION IN SMALL INTESTINE MAJOR SITE OF FAT DIGESTION DIGESTIVE ENZYMES PRESENT IN PANCREATIC JUICE ARE RESPONSIBLE FOR DIGESTION 1. PANCREATIC LIPASE 2. PHOSPHOLIPASE A 2 3. CHOLESTEROL ESTERASE

PANCREATIC LIPASE Hydrolyse the FA esterified to the 1 st and 3 rd carbon atoms of glycerol forming 2- monoacylglycerol & 2 molecules of FA. PHOSPHOLIPASES Are responsible for the hydrolysis of phospholipids. CHOLESTEROL ESTERASES: Cleaves cholesterol ester to produce cholesterol & FFA.

Remember “hydrolysis?”

BILE SALTS BILE SALTS HELP BINDING OF LIPASE WITH TWO MOLECULES OF COLIPASE COMBINATION ENHANCES LIPASE ACTIVITY IN THE INTESTINAL PH HELPS IN EMULSIFICATION OF FATS. CALCIUM PRECIPITATES FFA AS INSOLUBLE Ca SOAPS AND FACILITATES LIPASE ACTION.

MIXED MICELLE FORMATION BILE SALTS AND SOAPS FORMED IN THE INTESTINAL LUMEN AND BICARBONATE OF PANCREATIC AND INTESTINAL JUICES COLLECT THE HIGHER FA, MONO AND DIGLYCERIDES, LECITHINS, CHOLESTEROL IN THE FORM OF WATER SOLUBLE MOLECULAR AGGREGATES CALLED “MICELLES”.

MICELLES ARE ABSORBED MAINLY FROM DUODENUM AND JEJUNUM BILE SALTS ARE ABSORBED IN THE LOWER PART OF THE INTESTINE AND RETURN TO LIVER VIA PORTAL VEIN AND RESECRETED INTO THE BILE. KNOWN AS ENTEROHEPATICCIRCULATION.

Liposome

Lipid Absorption Big lipid fragments Monoglycerides and LCFAs need help! If absorbed into the blood: They need to be emulsified.

Big lipid fragments, cont. Enter intestinal cell, re-form TG TG is incorporated into Lipoprotein carriers: Chylomicrons (CM) Lipoprotein = lipid associated w/proteins “Shuttle” Protein and phospholipid act as emulsifiers for the other lipids

Lymph vessel    The tissues can extract what they need from the CMs. CM remnants  