BM SPL PB Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+

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BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Tumor Burden BM SPL PB Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+ Beads & Nucleated HLA-ABC+ (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (Vehicle) (Vehicle) 5153 5150 5174 5151 5152 5165

(From Apoptosis Assay) BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Tumor Burden (From Apoptosis Assay) BM SPL PB Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ 5153 5150 5174 5151 5152 5165 (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) 20mg/kg I-BET) (Vehicle) (Vehicle)

(From Apoptosis Assay) BET-EFF (MV-4-11): 6/1/16 & 6/2/16 (16 & 17 Days Rx) Sacrificing 1 + 3 Mice – Tumor Burden (From Apoptosis Assay) BM SPL MV-4-11 Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ Live Cells Nucleated cells HLA-ABC+ (20mg/kg I-BET) (Vehicle) (20mg/kg I=BET) (Vehicle) PB 5158 5177 5173 5170 Live Cells Nucleated cells HLA-ABC+

BET-EFF (MV-4-11): 6/6/16 (21 Days Rx) Sacrificing 6 Mice – Apoptosis (Annexin V Assay) BM SPL PB HLA-ABC+ Annexin V vs IP HLA-ABC+ Annexin V vs PI HLA-ABC+ Annexin V vs PI (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (20mg/kg I-BET) (Vehicle) (Vehicle) 5153 5150 5174 5151 5152 5165

BET-EFF (MV-4-11): 6/1/16 & 6/2/16 (16 & 17 Days Rx) Sacrificing 1 + 3 Mice – Apoptosis (Annexin V Assay) BM SPL MV-4-11 HLA-ABC+ Annexin V vs IP HLA-ABC+ Annexin V vs PI HLA-ABC+ Annexin V vs PI (20mg/kg I-BET) (Vehicle) 20mg/kg I=BET) (Vehicle) 5158 5177 5173 5170 PB HLA-ABC+ Annexin V vs PI