From: A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation Ann Intern Med. 1999;130(6):461-470. doi:10.7326/0003-4819-130-6-199903160-00002 Figure Legend: Relation of serum creatinine concentration to measured glomerular filtration rate (GFR).125crnndashed lines and dotssolid lines and circlescrnnPnnP2−2−2Each point represents the baseline measurement for one patient during the MDRD Study. Glomerular filtration rate was measured as the renal clearance of I-iothalamate. Serum creatinine concentration (P ) was measured by using a kinetic alkaline picrate assay. Values are shown separately for men ( = 915) and women ( = 586) by ethnicity (white persons [ ] and black persons [ ]). Regression lines were computed from the relation 1/P compared with GFR. Black men ( = 113) have higher serum creatinine values than white men ( = 802) ( < 0.001); black women ( = 84) have higher serum creatinine values than white women ( = 502) ( < 0.001). To convert mL/min per 1.73 m to mL • s • m , multiply by 0.00963. To convert mg/dL to µmol/L, multiply by 88.4. Date of download: 10/29/2017 Copyright © American College of Physicians. All rights reserved.

From: A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation Ann Intern Med. 1999;130(6):461-470. doi:10.7326/0003-4819-130-6-199903160-00002 Figure Legend: Relation of measured creatinine and urea clearances and transformations of serum creatinine concentration (Pcr) to measured glomerular filtration rate (GFR).n125A.B.C.D.E.crcrcrcrcrcr22−2−2Each point represents the baseline measurement during the Modification of Diet in Renal Disease Study ( = 1628). Correlations are shown for GFR, measured as the renal clearance of I-iothalamate. Solid lines are lines of identity. Creatinine clearance. Urea clearance. The mean of creatinine and urea clearances. Reciprocal of serum creatinine, ×100. Creatinine clearance estimated by the Cockcroft-Gault formula: C = [(140 − age) × weight]/(P × 72) for men or C = [(140 − age) − weight]/(P × 85) for women, where C is creatinine clearance and is given in mL/min, P is serum creatinine concentration and is given in mg/dL, age is given in years, and weight is given in kg. Estimated creatinine clearance was then adjusted for body surface area and expressed per 1.73 m . To convert mL/min to mL/s, multiply by 0.01667; to convert mL/min per 1.73 m to mL • s • m , multiply by 0.00963; to convert mg/dL to µmol/L, multiply by 88.4. Date of download: 10/29/2017 Copyright © American College of Physicians. All rights reserved.

From: A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation Ann Intern Med. 1999;130(6):461-470. doi:10.7326/0003-4819-130-6-199903160-00002 Figure Legend: Relation of predicted glomerular filtration rate (GFR) to measured GFR.nTop.Bottom.2−2−2Each point represents the baseline measurement during the Modification of Diet in Renal Disease (MDRD) Study ( = 1628). Glomerular filtration rate predicted by using MDRD Study equation 6. Glomerular filtration rate predicted by using MDRD Study equation 7. Solid lines are lines of identity. To convert mL/min per 1.73 m to mL • s • m , multiply by 0.00963. Date of download: 10/29/2017 Copyright © American College of Physicians. All rights reserved.

From: A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation Ann Intern Med. 1999;130(6):461-470. doi:10.7326/0003-4819-130-6-199903160-00002 Figure Legend: Comparison of equations to predict glomerular filtration rate (GFR).R 2 nnR 2 crureacrThe values of indicate the percentage of variance of log GFR accounted for in the validation sample ( = 558) by equations derived from the training sample ( = 1070). The values of 1 − indicate the percentage of variance in log GFR that is unexplained by each equation. C = creatinine clearance; C = urea clearance; P = serum creatinine concentration. Date of download: 10/29/2017 Copyright © American College of Physicians. All rights reserved.