Adherence with montelukast or fluticasone in a long-term clinical trial: Results from the Mild Asthma Montelukast Versus Inhaled Corticosteroid Trial

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Presentation transcript:

Adherence with montelukast or fluticasone in a long-term clinical trial: Results from the Mild Asthma Montelukast Versus Inhaled Corticosteroid Trial Cynthia Rand, PhD, Andrew Bilderback, MS, Kathleen Schiller, PhD, Jonathan M. Edelman, MD, Carolyn M. Hustad, PhD, Robert S. Zeiger, MD, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 4, Pages 916-923 (April 2007) DOI: 10.1016/j.jaci.2006.12.664 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 MIAMI study design. Schematic showing the 3 periods of MIAMI. Continuous electronic monitoring of adherence took place during all 3 periods. Reprinted with permission from Zeiger RS, Bird SR, Kaplan MS, Schatz M, Pearlman DS, Orav EJ, et al. Short-term and long-term asthma control in patients with mild persistent asthma receiving montelukast or fluticasone: a randomized controlled trial. Am J Med 2005;118:649-57. Journal of Allergy and Clinical Immunology 2007 119, 916-923DOI: (10.1016/j.jaci.2006.12.664) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Dose-response relationship between active treatment and study outcomes: DB. Line graphs showing the results of the regression analysis for change in FEV1 percent predicted (A) and change in percentage of asthma RFDs (%RFD) with adherence to fluticasone or montelukast (B) for patients with baseline FEV1 percent predicted ≤86%, >86%, and for all participants. Journal of Allergy and Clinical Immunology 2007 119, 916-923DOI: (10.1016/j.jaci.2006.12.664) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Dose-response relationship between active treatment and study outcomes: OL. Line graphs showing the results of the regression analysis for change in FEV1 percent predicted (A) and change in percentage of asthma RFDs (%RFD) with adherence to fluticasone or montelukast (B) for patients with baseline FEV1 percent predicted ≤86%, >86%, and for all participants. Journal of Allergy and Clinical Immunology 2007 119, 916-923DOI: (10.1016/j.jaci.2006.12.664) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions