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The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5- year follow-up: Effectiveness of early intervention with budesonide in.

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Presentation on theme: "The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5- year follow-up: Effectiveness of early intervention with budesonide in."— Presentation transcript:

1 The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5- year follow-up: Effectiveness of early intervention with budesonide in mild persistent asthma  William W. Busse, MD, Søren Pedersen, MD, Romain A. Pauwels, MD, Wan C. Tan, MD, Yu-Zhi Chen, MD, Carl Johan Lamm, PhD, Paul M. O'Byrne, MD  Journal of Allergy and Clinical Immunology  Volume 121, Issue 5, Pages (May 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Study design. Patients were randomized to double-blind treatment with inhaled budesonide, 200 μg (aged <11 years) or 400 μg once daily through a Turbuhaler, or placebo plus usual asthma therapy for 3 years. After 3 years, all patients received 2 years of open-label treatment with inhaled budesonide once daily plus usual asthma therapy. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Patient disposition during the 2-year open-label phase of the study. The number of patients who received double-blind treatment was 7221. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Mean postbronchodilator (A) and prebronchodilator (B) percent predicted FEV1 among patients in the budesonide and reference groups completing all 5 years of the study. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Cumulative probability of having a first SARE. The curves are based on life-table estimates (interval width, 0.25 years) by using all patients entered into the study. The number of patients at risk in the budesonide (Reference) group is 3597 (3568) at time 0, 2613 (2486) at time 2.50 years, and 2337 (2195) at time 4.50 years. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Mean percentage of symptom-free days (SFDs) among patients in the budesonide and reference groups completing all 5 years of the study. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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