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Differential effects of maintenance long-acting β-agonist and inhaled corticosteroid on asthma control and asthma exacerbations  Peter G. Gibson, MBBS(Hons),

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Presentation on theme: "Differential effects of maintenance long-acting β-agonist and inhaled corticosteroid on asthma control and asthma exacerbations  Peter G. Gibson, MBBS(Hons),"— Presentation transcript:

1 Differential effects of maintenance long-acting β-agonist and inhaled corticosteroid on asthma control and asthma exacerbations  Peter G. Gibson, MBBS(Hons), FRACP, Heather Powell, MMedSci, Francine M. Ducharme, MD, FRCP  Journal of Allergy and Clinical Immunology  Volume 119, Issue 2, Pages (February 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 LABA/ICS vs similar ICS dose (ICS-naive)10 metaview including studies reporting all 3 outcomes. FP, Fluticasone propionate. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 LABA/ICS vs similar ICS dose11 metaview including studies reporting all 3 outcome. ICSNR, Inhaled corticosteroid type not reported. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 LABA/ICS vs higher ICS dose12 metaview including studies reporting all 3 outcomes. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Efficacy of LABA/ICS on asthma control and exacerbations. Similar (ICS-naive): LABA/ICS vs similar dose ICS alone in steroid-naive inadequately controlled asthma.10 Asthma control: N trials = 5; N subjects = 968. Exacerbations: N trials = 3; N subjects = 514. Similar: LABA/ICS vs a similar maintenance dose ICS alone in inadequately controlled asthma.11 Asthma control: N trials = 13; N subjects = Exacerbations: N trials = 12; N subjects = Higher: LABA/ICS vs a higher maintenance dose ICS alone in inadequately controlled asthma.12 Asthma control: N trials = 14; N subjects = Exacerbations: N trials = 13; N subjects = A positive SMD favors LABA/ICS; a negative SMD favors ICS. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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