CHM 708 Anti-Bacterial Drugs.

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Presentation transcript:

CHM 708 Anti-Bacterial Drugs

Drugs targeting the bacterial cell wall Cell wall cross-linking inhibitors (b-lactams) Penicillins Cephalosporins Carbapenems Monobactams Cell wall peptide synthesis inhibitors

Penicillins

Acid hydrolysis

Acid and/or b-lactamase resistant penicillins

Broad spectrum penicillins

Cephalosporins

Semi-synthetic cephalosporins

Oximino-cephalosporins

Other b-lactam antibiotics

Antibiotics with surface activity

Inhibitors of bacterial protein synthesis Tetracyclines Aminoglycosides Chloramphenicol Macrolides

Tetracyclines

Aminoglycosides

Neomycin and chloramphenicol

Macrolides

Inhibitors of bacterial nucleic acid synthesis Sulphonamides Rifamycins Quinolones (fluoroquinolones)

Sulphonamides

Action of sulphonamides, sulphones, etc.

Rifamycins

Fluoroquinolones

Anti-tuberculosis drugs First line drugs Streptomycin Rifampicin Isoniazid Ethambutol Pyrazinamide Second line drugs Kanamycin Ethionamide Fluoroquinolones (ciprofloxacin, levofloxacin, sparfloxacin)

Drugs for treating leprosy Also levofloxacin rifampicin

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