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2004-2005 Principles of Medical Science Pharmacology Review
28 April :51 PM
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Amikacin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
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Aminoglycosides Antibiotics Bactericidal protein synthesis inhibitors
30S ribosome Freeze initiation
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Amoxicillin Penicillin antibiotic Cell wall synthesis inhibitor Antiulcer Amino penicillin Inhibits peptidoglycan cross-linking
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Ampicillin Penicillin antibiotic Cell wall synthesis inhibitor
Amino penicillin Inhibits peptidoglycan cross-linking
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Azithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation
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New b lactam antibiotic
Aztreonam New b lactam antibiotic Monobactam
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Bacitracin Antibiotic Cell wall synthesis inhibitor
Topical, not a b lactam, Inhibits dephosphorylation of bactoprenol
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Benzathine penicillin G
Penicillin antibiotic Cell wall synthesis inhibitor Inhibits peptidoglycan cross-linking Repository preparation
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Carbenicillin Penicillin antibiotic Cell wall synthesis inhibitor
Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Cefaclor Cephalosporin antibiotic Cell wall synthesis inhibitor 2nd generation Oral
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Cefadroxil Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
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Cefepime Cephalosporin antibiotic Cell wall synthesis inhibitor
4th generation CSF penetration
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Cefotaxime Cephalosporin antibiotic Cell wall synthesis inhibitor
3rd generation CSF penetration
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Cefoxitin Cephalosporin antibiotic Cell wall synthesis inhibitor 2nd generation
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Ceftazidime Cephalosporin antibiotic Cell wall synthesis inhibitor 3rd generation
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Ceftriaxone Cephalosporin antibiotic Cell wall synthesis inhibitor
3rd generation CSF penetration
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Cefuroxime Cephalosporin antibiotic Cell wall synthesis inhibitor
2nd generation CSF penetration
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Cephalexin Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
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Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan
Cephalosporins Antibiotics b lactam Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan
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Cephalosporin antibiotic Cell wall synthesis inhibitor
Cephalothin Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
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Chloramphenicol Antibiotic Bacteriostatic protein synthesis inhibitor
50S ribosome Inhibits peptide bond formation
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Ciprofloxacin Fluoroquinolone antibiotic DNA replication inhibitor
Inhibits bacterial DNA gyrase
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50S ribosome Inhibits translocation
Clarithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 50S ribosome Inhibits translocation
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b-lactamase inhibitor Combined with antibacterials
Clavulanic acid b-lactamase inhibitor Combined with antibacterials
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Clindamycin Antibiotic Bacteriostatic protein synthesis inhibitor
50S ribosome Anaerobic infections
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Penicillin antibiotic Cell wall synthesis inhibitor
Cloxacillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking
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Cycloserine Antibiotic Cell wall synthesis inhibitor
Secondary TB drug Inhibits formation of Park nucleotide
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Dapsone Sulfone antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Leprosy
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Doxycycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
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Erythromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation
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Fluorinated Quinolones ciprofloxacin, norfloxacin
Antibiotics DNA replication inhibitors Inhibit bacterial DNA gyrase
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Gentamicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
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Imipenem/Cilastatin New b lactam antibiotic
Cilastatin inhibits a kidney dipeptidase that inactivates imipenem
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Oxazolidinone antibiotic Protein synthesis inhibitor
Linezolid Oxazolidinone antibiotic Protein synthesis inhibitor 50S ribosomal subunit
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Macrolides erythromycin, azithromycin, clarithromycin
Antibiotics Bacteriostatic protein synthesis inhibitors 50S ribosome
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Methicillin Penicillin antibiotic Cell wall synthesis inhibitor
Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking
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Metronidazole Antibiotic Antiparasitic Antiulcer
Anaerobes Reduction leads to intermediates that damage DNA
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Minocycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
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Penicillin antibiotic Cell wall synthesis inhibitor
Nafcillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking
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Neomycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation Topical
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Netilmicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
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Norfloxacin Fluoroquinolone antibiotic DNA replication inhibitor
Inhibits bacterial DNA gyrase
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Oxacillin Penicillin antibiotic Cell wall synthesis inhibitor
Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking
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Oxytetracycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
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Para-aminosalicylic acid
Antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Secondary TB drug
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Penicillins b lactam antibiotics Cell wall synthesis inhibitors
Inhibit cross-linking of peptidoglycan
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Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor
Acid labile Inhibits peptidoglycan cross-linking
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Penicillin antibiotic Cell wall synthesis inhibitor
Penicillin V Penicillin antibiotic Cell wall synthesis inhibitor More acid resistant than Penicillin G Inhibits peptidoglycan cross-linking
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Piperacillin Penicillin antibiotic Cell wall synthesis inhibitor
Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
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Polymyxin B Antibiotic Disrupts gram negative cell membrane
Binds phosphatidylethanolamine Bactericidal
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Adjunct in penicillin therapy
Probenecid Uricosuric Adjunct in penicillin therapy
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Procaine Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Repository preparation Inhibits peptidoglycan cross-linking
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Quinopristin/Dalfopristin
Streptogramin antibiotic Protein synthesis inhibitor 50S ribosomal subunit
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Rifampin Antibiotic Nucleic acid synthesis inhibitor
Inhibits DNA dependent RNA polymerase Major drug for TB
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Inhibits dihydropteroate synthetase Topical
Silver sulfadiazine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical
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Antibiotic Bacteriostatic protein synthesis inhibitor
Spectinomycin Antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome
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Streptomycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
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Inhibits dihydropteroate synthetase Topical
Sulfacetamide Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical
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Dihydropteroate synthetase inhibitor
Sulfadoxine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Dihydropteroate synthetase inhibitor
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Inhibits dihydropteroate synthetase
Sulfamethoxazole Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase
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Sulfisoxazole Sulfonamide antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase
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Sulfonamides Antibiotics Nucleic acid and protein synthesis inhibitors
Inhibit dihydropteroate synthetase
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Tetracycline Antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 30S ribosome Prevents aminoacyl tRNA attachment
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Ticarcillin Penicillin antibiotic Cell wall synthesis inhibitor
Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
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Tobramycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
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Trimethoprim Antibiotic Protein and nucleic acid synthesis inhibitor
Folic acid antagonist Inhibits bacterial dihydrofolate reductase
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Antibiotic Inhibits cell wall synthesis
Vancomycin Antibiotic Inhibits cell wall synthesis Not a b lactam
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