PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers  Xiao-Ping Zhou, Anu.

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PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers  Xiao-Ping Zhou, Anu Loukola, Reijo Salovaara, Minna Nystrom-Lahti, Päivi Peltomäki, Albert de la Chapelle, Lauri A. Aaltonen, Charis Eng  The American Journal of Pathology  Volume 161, Issue 2, Pages 439-447 (August 2002) DOI: 10.1016/S0002-9440(10)64200-9 Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 1 PTEN protein expression (brown chromogenic reaction) in colorectal carcinomas (CRCs). a and b: Adjacent normal colonic epithelium showing strong cytoplasmic (++) and nuclear PTEN expression (+/++). c and d: CRC showing cytoplasmic PTEN expression (++). e and f: CRC with weak cytoplasmic PTEN immunoreactivity (+). Of note, the PTEN nuclear staining in colon carcinoma cells is remarkably weaker or absent compared to that of adjacent normal colonic epithelium. g and h: CRC exhibiting no PTEN expression (−) in all tumor cells. Original magnifications: ×4 (a, c, e, g); ×20 (b, d, f, h). The American Journal of Pathology 2002 161, 439-447DOI: (10.1016/S0002-9440(10)64200-9) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

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