Comparison of the efficacy and safety of single-agent and doublet chemotherapy in advanced non-small cell lung cancer in the elderly: A meta-analysis

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Comparison of the efficacy and safety of single-agent and doublet chemotherapy in advanced non-small cell lung cancer in the elderly: A meta-analysis Gaetan Des Guetz, Bernard Uzzan, Patrick Nicolas, Dominique Valeyre, Georges Sebbane, Jean-François Morere Critical Reviews in Oncology / Hematology Volume 84, Issue 3, Pages 340-349 (December 2012) DOI: 10.1016/j.critrevonc.2012.03.007 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Flow-chart of the meta-analysis. Critical Reviews in Oncology / Hematology 2012 84, 340-349DOI: (10.1016/j.critrevonc.2012.03.007) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Forest plot of studies including or not a platinum salt and assessing overall survival. By convention, a Hazard Ratio<1 corresponds to a higher survival for doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology 2012 84, 340-349DOI: (10.1016/j.critrevonc.2012.03.007) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Forest plot of studies including or not a platinum salt and assessing response rate. By convention, a Hazard Ratio<1 corresponds to higher response for doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology 2012 84, 340-349DOI: (10.1016/j.critrevonc.2012.03.007) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Forest plot of studies including or not a platinum salt and assessing toxicities. By convention, a Hazard Ratio>1 corresponds to a higher frequency of side effect among patients receiving doublet chemotherapy compared with single agent. Critical Reviews in Oncology / Hematology 2012 84, 340-349DOI: (10.1016/j.critrevonc.2012.03.007) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions