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Eribulin—A review of preclinical and clinical studies

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1 Eribulin—A review of preclinical and clinical studies
Umang Swami, Imran Chaudhary, Mohammad H. Ghalib, Sanjay Goel  Critical Reviews in Oncology / Hematology  Volume 81, Issue 2, Pages (February 2012) DOI: /j.critrevonc Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Chemical structure of halichondrin B.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Chemical structure of eribulin mesylate.
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Mechanism of action of eribulin (courtesy EISAI).
Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Plasma Cmax versus dose following a 1-h infusion of eribulin on day 1. (B) Plasma area under the concentration–time curve (AUC0-8) versus dose following a 1-h infusion of eribulin on day 1. (C) Plasma concentration versus time profile for the 1.0mg/m2 treatment group (n=9). From: Ref. [10]. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Eribulin related adverse events of interest or ≥10% incidence as seen in 394 patients with MBC [55,56]. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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