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Critical Reviews in Oncology / Hematology

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1 Critical Reviews in Oncology / Hematology
Efficacy and mucosal toxicity of concomitant chemo-radiotherapy in patients with locally- advanced squamous cell carcinoma of the head-and-neck in the light of a novel mathematical model  Lidia Strigari, Paola Pinnarò, Paolo Carlini, Francesco Torino, Silvia Strolin, Silvia Minosse, Giuseppe Sanguineti, Marcello Benassi  Critical Reviews in Oncology / Hematology  Volume 102, Pages (June 2016) DOI: /j.critrevonc Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Odd ratio (OR) based on 5-year overall survival (5y-OS) for randomized trials comparing cisplatin- (i.e. DDP) (a) and carboplatin- (carbo) based (b) concomitant radio-chemotherapy to radiotherapy alone. For trial identification see Tables 1 and 2. Columns CRT and RT-alone indicate the number of death/number of patients for the corresponding treatment arm. Abbreviations: Q=the weighted sum of squares on a standardized scale; DF=the degree of freedom; 95% CI=indicates the 95% confidence interval; P=the p-value. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 The 5-year overall survival (5y-OS) against equivalent dose at 2Gy/fraction (EQD2) curve for cisplatin- (DDP-) and carboplatin- (carbo-) based chemotherapy. The size of the symbols represents the logarithm of chemo-sensitization fraction (CSF). The solid lines shows the multivariate logistic model prediction reported in Table 3, while the dashed lines are the lowest/highest values of CSF (i.e. 7 and 100%, respectively). Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 The ≥G3-mucositis rate against the equivalent dose at 2Gy/fraction (EQD2) distinguishing chemotherapy with/without concurrent 5-Fluorouracil (Fu). The solid lines show the multivariate logistic model prediction reported in Table 4. Critical Reviews in Oncology / Hematology  , DOI: ( /j.critrevonc ) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions


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