Percentile lines for the relationship between insulin sensitivity (SI) and the first-phase insulin response (AIRglucose) based on data from 93 normal subjects.45.

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Percentile lines for the relationship between insulin sensitivity (SI) and the first-phase insulin response (AIRglucose) based on data from 93 normal subjects.45 Mean data from four other studies are plotted. Thirteen healthy older subjects demonstrate that aging is associated with a reduction in β-cell function.51 Reduced β-cell function is also manifest in 8 women with a history of gestational diabetes (GDM),68 11 women with polycystic ovarian disease (PCO) and a family history of type 2 diabetes,59 and in 14 subjects with a first-degree relative with type 2 diabetes.4 The reduction in β-cell function in these groups is compatible with their high risk of subsequently developing type 2 diabetes. (Reproduced from Kahn.4 Used with permission.) Source: β-Cell Dysfunction in Type 2 Diabetes: Pathophysiological and Genetic Bases, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch67fg6.png&sec=62671469&BookID=971&ChapterSecID=62671419&imagename= Accessed: October 10, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved