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Light micrographs comparing pycnodysostosis and normal bone

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Presentation on theme: "Light micrographs comparing pycnodysostosis and normal bone"— Presentation transcript:

1 Light micrographs comparing pycnodysostosis and normal bone
Light micrographs comparing pycnodysostosis and normal bone. Bone biopsies taken from a normal individual (left) and a child with pycnodysostosis (right) demonstrate that both cortical and trabecular bone are excessively thick in pycnodysostosis. The marrow space is narrowed but the cellular elements are preserved in the disorder (von Kossa staining; ×12.5 magnification). (Courtesy of Michael Klein, Mount Sinai School of Medicine, New York, NY.) Source: Pycnodysostosis: Cathepsin K Deficiency, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: October 17, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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