1. Structure and mutation spectrum of BRCA1
Structure and mutation spectrum of BRCA1. Diagram demonstrating even distribution of mutations across the BRCA1 coding sequence. The 24 exons of BRCA1 are represented by vertical lines within the gene. Mutations are depicted beneath the BRCA1 exon where the mutation occurrs. Mutations are categorized according to recurrance and mutation type, as shown in the accompanying key. The idiogram was copied from the Breast Cancer Information Core (BIC) Web site and was generated by Simon Gayther, Cambridge, U.K.
Source: Breast Cancer, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 10, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved