Translation. The enzyme: Amminoacyl-tRNA synthetase.

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Presentation transcript:

Translation

The enzyme: Amminoacyl-tRNA synthetase

Polymerization

The factory

Figura 8.3 Small subunit Large subunit

Regulation of gene expression

Regulation of protein stability

The proteasome

Figure 6-92b Molecular Biology of the Cell (© Garland Science 2008) Polyubiquitination marks proteins that should be degraded

Figure 6-92c Molecular Biology of the Cell (© Garland Science 2008)

Figure 6-93 Molecular Biology of the Cell (© Garland Science 2008)

Regulation of translation

5’ 3’ coding Regulation UTR

Regulation of translation by miRNAs

Regulation of translation by mTORC1

Translation mTORC 1 S6K1 4EBP1 TIF1 A UBF SL1 RNA Pol I transcription rRNA eIF4E tRNA RNA Pol III transcription RNA Pol III transcription 4EBP1 P P MAF1 P inattivo attivo attiva inattiva attiva + + -

Protein synthesis

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