IP integration of pathology and histology Lija Joseph MD

Do you see why such tumors can be palpable by digital rectal examination?

Normal prostate Benign prostate glands are lined by two cell layers, simple columnar epithelium lined glands resting on a cuboidal cell layer. The glands are scattered in a fibromuscular stroma. Concretions called corpora amylacea (rice bodies) are often seen in benign prostate glands.

Adenocarcinoma of Prostate Malignant prostate glands lose the two cell layer architecture. They glands are lined by single cell layer. The cells have prominent nucleoli and crystalloid structures may be seen in the lumen. Special stains (like Keratin 903) to identify the basal cuboidal cells are utilized to document the absence of two cell layers.

Gleason score Gleason’s scoring method identifying specific pattern of tumor architecture is used in determining the grade of prostate cancer. The higher the grade the worse prognosis.

Gleason score