CIN Cytological features: Cytological features: - loss in the uniformity of the individual cells - loss in the uniformity of the individual cells - considerable pleomorphism - hyperchromatic and enlarged nuclei - more abundant mitotic figures also in abnormal locations within epithelium Loss of the typical architectural orientation of cells Intact basal membrane review a few slides as they differ in grade (CIN 1 and CIN 2)
Adenocarcinoma (large intestine) Cytologically malignant columnar cells forming neoplastic glands, often cribriform, with central necrosis. Differentiation may range from tall, columnar cells to undifferentiated, frankly anaplastic masses.
Small cell lung carcinoma (= SCLC) The epithelial cells are small, with scant cytoplasm, ill- defined cell borders, finely granular nuclear chromatin (salt and pepper pattern), and absent or inconspicuous nucleoli. The cells are round, oval, and spindle-shaped, and nuclear molding is prominent. In general, tumor cells are smaller than small resting lymphocytes. The mitotic count is high. The cells grow in clusters that exhibit neither glandular nor squamous organization. Necrosis is common and often extensive. Grading is inappropriate, since all small cell carcinomas are high grade.