Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular Endothelial Growth Factor in the Retina: New Insights Into the Pathogenesis of Capillary Nonperfusion Arch Ophthalmol. 2001;119(6): doi: /archopht Immunohistochemical staining of cryosections of the retina with the panendothelial cell marker CD31 of a phosphate-buffered saline–injected monkey eye (A) and a vascular endothelial growth factor A (VEGF)–injected eye (B). Note the larger size, but normal distribution, of capillaries in the VEGF-injected eye (arrowheads) (original magnification ×350). Figure Legend:

Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular Endothelial Growth Factor in the Retina: New Insights Into the Pathogenesis of Capillary Nonperfusion Arch Ophthalmol. 2001;119(6): doi: /archopht Light micrographs of cross sections of retina in a phosphate-buffered saline (PBS)–injected monkey eye (A) and a vascular endothelial growth factor A (VEGF)–injected eye (B). Note the large empty lumina in the PBS-treated retina (arrowheads, A) and their absence in the VEGF-treated retina (arrowheads, B) (original magnification ×350). Figure Legend:

Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular Endothelial Growth Factor in the Retina: New Insights Into the Pathogenesis of Capillary Nonperfusion Arch Ophthalmol. 2001;119(6): doi: /archopht Diagram of the total luminal area of capillaries in the inner nuclear layer, per millimeter of retina, in the phosphate-buffered saline (PBS)–injected eyes and in the vascular endothelial growth factor A (VEGF)–injected eyes of both monkeys (P<.01). n indicates number of retinal sections examined; error bars, SEMs. Figure Legend:

Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular Endothelial Growth Factor in the Retina: New Insights Into the Pathogenesis of Capillary Nonperfusion Arch Ophthalmol. 2001;119(6): doi: /archopht Electron micrographs of capillaries in the inner nuclear layer of the retina in the phosphate-buffered saline–injected monkey eye (A, B), and vascular endothelial growth factor A (VEGF)–injected monkey eye (C, D). Note the small lumina (L) (arrows) and endothelial cell(E) hypertrophy in the retinal capillaries of the VEGF-injected eye (original magnification ×15 000). Figure Legend:

Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular Endothelial Growth Factor in the Retina: New Insights Into the Pathogenesis of Capillary Nonperfusion Arch Ophthalmol. 2001;119(6): doi: /archopht Diagram illustrating the mean relative volume occupied by the capillary lumen and endothelial cell cytoplasm of individual retinal capillaries in the inner nuclear layer of the phosphate-buffered saline (PBS)–injected and vascular endothelial growth factor A (VEGF)–injected eyes. Note the significant increase (P<.001) in endothelial cell volume in capillaries in the VEGF-injected eyes and the significant decrease (P<.001) in luminal volume of these capillaries compared with the PBS-injected eyes. n indicates number of individual capillaries studied; error bars, SEMs. Figure Legend: