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Copyright © 1998 American Medical Association. All rights reserved.

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Presentation on theme: "Copyright © 1998 American Medical Association. All rights reserved."— Presentation transcript:

1 Copyright © 1998 American Medical Association. All rights reserved.
From: A Mouse Model of Acute Bacterial Rhinosinusitis Arch Otolaryngol Head Neck Surg. 1998;124(11): doi: /archotol Figure Legend: Three paraffin-embedded coronal sections of a mouse nasal cavity stained with hematoxylin-eosin. Sections are representative of anterior (A), middle (B), and posterior (C) regions of the nose. All 3 sections show an obvious central nasal septum and turbinates. Arrows indicate maxillary sinuses (original magnification ×10). Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.

2 Copyright © 1998 American Medical Association. All rights reserved.
From: A Mouse Model of Acute Bacterial Rhinosinusitis Arch Otolaryngol Head Neck Surg. 1998;124(11): doi: /archotol Figure Legend: Examples of sinus mucosa of control mice (A and B) and those inoculated 5 days previously with broth or Streptococcus pneumoniae (C and D). The infected mice show neutrophil clusters (arrowhead) within the sinus air spaces and neutrophils infiltrated within the sinus mucosa (original magnification: A and C, ×100; B and D, ×500). Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.

3 Copyright © 1998 American Medical Association. All rights reserved.
From: A Mouse Model of Acute Bacterial Rhinosinusitis Arch Otolaryngol Head Neck Surg. 1998;124(11): doi: /archotol Figure Legend: Percentage of sinuses filled with neutrophil clusters in mice infected with Streptococcuspneumoniae. The number of clusters appears to peak on day 5 and to decrease by 2 weeks. Mice challenged with broth only (used to deliver the Spneumoniae) and examined on days 5 (n=6) and 14 (n=2) did not show any neutrophil clusters (data not plotted). The difference between controls and infected mice on day 5 was significant (P<.001). PMN indicates polymorphonuclear neutrophils. Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.

4 Copyright © 1998 American Medical Association. All rights reserved.
From: A Mouse Model of Acute Bacterial Rhinosinusitis Arch Otolaryngol Head Neck Surg. 1998;124(11): doi: /archotol Figure Legend: Neutrophils per square millimeter of sinus mucosa in mice exposed to Streptococcus pneumoniae or broth (controls). The number of neutrophils appears to peak on day 5 and to decrease by 2 weeks. The difference between controls and infected mice on day 5 was significant (P<.002). No day 2 controls have been evaluated to date. PMN indicates polymorphonuclear neutrophils. Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.

5 Copyright © 1998 American Medical Association. All rights reserved.
From: A Mouse Model of Acute Bacterial Rhinosinusitis Arch Otolaryngol Head Neck Surg. 1998;124(11): doi: /archotol Figure Legend: Correlation between the density of cultures of Streptococcus pneumoniae recovered at killing on day 5 and the number of polymorphonuclear neutrophils per square millimeter (PMN/mm2). The culture density was rated as 1, few; 2, moderate; and 3, many colonies. We were able to yield Streptococcus from all mice inoculated with bacteria and we were unable to yield Streptococcus from mice inoculated with broth. There was no correlation between the culture density and the severity of the tissue reaction on day 5. Similar results were found for the correlation between neutrophil cluster and culture density. Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.


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