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Human embryonic stem cells Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007.

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Presentation on theme: "Human embryonic stem cells Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007."— Presentation transcript:

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2 Human embryonic stem cells

3 Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007

4 Proteomic comparison 14 days of analysis 15,091 phosphorylation sites 7,962 unique proteins

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8 Multiplexed enrichment analysis

9 Chromatin Modifying Proteins Note reversed scale

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13 Protein-protein interactions

14 Becker, KA. et al Journal of Cellular Physiology 2007

15 Reprogramming networks

16 Cyclin-dependent kinase 2

17 mRNA up, protein down

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22 Kinase Analysis

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