1. Moein Farshchian Ph.D Candidate of Cell and Molecular Biology

2. * GENOMICS: A “Discipline” Less than 25 Years Old Victor A. McKusick

3. 2. Comparative Genomics: Study of Conservation and Divergence of Genomes of Different Organisms 3. Functional Genomics: Development and Application of Global Approaches to Assess Gene Function

5. * Comparative Genomics Olson et al., (2002)

9. * Naive Way of Extracting Genes

10. Same genome  Different tissues Different physiology Different proteome Different expression pattern Anise swallowtail, Papilio zelicaon

13. Figure 7-44 Molecular Biology of the Cell (© Garland Science 2008)

14. * Cancer

16. Figure 7-77b Molecular Biology of the Cell (© Garland Science 2008)

19. * Clonal Hetrogeny in Tumor

21. Metastasis

27. - very low The incidence of cancer in non-human primates is very low. -All examined human cancer genes (n=333) are present in chimpanzee, contain intact open reading frames and show a high degree of conservation between both species (99.38%) -. Puente et al., (2006)

29. * Induced pluripotent Stem Cell (iPS Cells)

35. * Nature Review Cancer, April 2007

39. * Thanks