1. DIA SIG 2007: What are the Issues? Why do we need a standard and what is wrong with the current software landscape in HCS/HCA? What problems do end-users encounter due to the lack of such a standard? What should such a standard encompass? If you were writing the standard, what features or capabilities would you include? There are now more than ten standards related to image and data exchange. Can we adopt one of them as is or with minor modifications? Is anything missing in the existing standards and what? Is there anything in these standards that we do not want and what? What is unique to the field of HCS/HCA? If there was an accepted standard, how would it change your workflow and purchasing decisions (user perspective)? How would it change your product development decisions (vendor perspective)? What are the technical issues, e.g., exchange format vs. native format, ease of import/export, difficulty of implementation, storage, access, etc.? How do we get from here to there? Who is interested enough to spend time and money? What are the steps and the timeline? How to reach consensus? How to get buy-in from vendors/developers?

2. Recent History of the D&IA (DA&IT) SIG YearLocationTopicAttendance 2002The HagueXML Standards~20 2003PortlandDose-Response Analysis~40 2004OrlandoAssay Quality Metrics~60 2005GenevaImage Analysis Algorithm Comparison ~60 2006SeattleImaging Modalities (widefield, confocal, LSC) 100+ 2007MontrealData Exchange Standard(s)~90

3. Program 1.Jeff Price, Burnham Institute for Medical Research, “Data Storage Challenges for Primary HCS in Burnham's NIH Molecular Libraries Screening Center” 2.Curtis Rueden, Lead Informatics Developer, Laboratory for Optical and Computational Instrumentation UW-Madison, "Open Microscopy Environment File Formats: OME-XML, OME-TIFF and Bio-Formats" 3.Mark Collins, Marketing Manager, Cellular Imaging & Analysis, Thermo Fisher Scientific, "MIAHA - Minimum Information for a High Content Assay - a proposal for a standard for high content analysis data interchange" 4.Seungtaek Lee, Senior Applications Scientist, Evotec Technologies (A PerkinElmer Company), "Interface Standards in HCS" 5.J. Paul Robinson, President, International Society for Analytical Cytology, "ISAC's perspective on data: standards, structure and analysis" 6.Ilya Ravkin, Imaging Consultant, "Why is this Standard Different From All Other Standards“ 7.(*) Patrick Courtney, PerkinElmer, Seer Green, UK "Economics of Standardization“ 8.(*) Robert C. Leif, Newport Instruments "Cytometry Standards Continuum" (*) These presentations will not be delivered orally but are available on the website For links to individual presentations, see http://www.ravkin.net/SBS/D&IA_SIG2007.htmhttp://www.ravkin.net/SBS/D&IA_SIG2007.htm