1. Driving Innovation Technology: High Value Manufacturing Robin Wilson Lead Technologist, High Value Manufacturing 29 th October 2009 UK Manufacturing Strategy Progress check - One Year On: NESTA, London 1

2. Driving Innovation Pod 1Pod 2Pod 3Pod 4Pod 5 3.10- 3.40 Global value chains - UKTI advanced engineering Donald McNeil Technology - High value manufacturing, Robin Wilson, Technology Strategy Board Intangibles - Designing Demand David Godber, Design Council Manufacturing Skills – an interactive session examining supply attraction and workforce development and then looking at skills for the future. Joanna Woolf, Cogent and Lynn Tomkins Semta Low Carbon Industrial Strategy Adam Cartwright, Office for Low Emission Vehicles 3.50- 4.10 UKTI – meet the companies exporting in and Meet some of the companies who have been working successfully with TSB Meet some of the companies where design has improved sales Manufacturing the Future: Pat Langford, Director of Programmes, STEMNET will lead a discussion on promoting Manufacturing as an exciting and dynamic career choice. Meet a company who are working hard to inspire young people. Meet companies who are operating successfully in low carbon markets 2

3. Driving Innovation Who are the Technology Strategy Board We are a national body set up to invest in business innovation We are sponsored by Department of Business, Innovation and Skills (BIS – our hosts today) We come from business (and the public sector) About 100 people, >1200 years of business experience We work across business, universities and Government We are responsible for investing £1bn 3

4. Driving Innovation We support the full range of business We help strengthen the global competitive position of our leading businesses We identify and grow sectors and businesses with the capacity to become the best in the world We nurture the businesses that can succeed in the growth sectors of tomorrow 4

5. Driving Innovation And we make choices We dont pick winners, we pick sectors where UK businesses can thrive and support innovative companies in them We consider the size of the markets, the capability of the UK to address them and the timing And the difference our support would make 5

6. Driving Innovation How we deliver 6

7. Driving Innovation Technology Inspired Innovation We build capability in the underpinning areas that enable a sure and effective response to market needs –Advanced materials –Bioscience –Electronics, photonics and electrical systems –Information and communication technologies –High value manufacturing –Nanotechnology 7

8. Driving Innovation Our Tools for Prioritisation and Delivery Published Technology Strategies –To communicate funding priorities and rationale eg: High Value Manufacturing Strategy (Sept 2008) –To provide clear, consistent focus for funding applicants Competitions – collaborative R&D projects eg: £24m High Value Mfg, launched January 2009 Additional funding mechanisms SBRI for R&D contracts (Government procurement) Large (>£5m) CR&D Projects, assessed on individual basis 8

9. Driving Innovation Our Investment (Assessment) criteria Can the UK do it? Is there a large market opportunity? Is the idea ready? Can the Technology Strategy Board make a difference? Model for success: a convincing yes to these 4 questions 9

10. Driving Innovation Manufacturing Strategy Working with Industry Working with Academia Working with Government Working together Developing a common understanding of challenges and opportunities Prioritising investment in key areas Publish Strategy, launch CR&D competitions 10

11. Driving Innovation Manufacturing Through Life Not just production Interfaces forwards and backwards HIGH VALUE MANUFACTURING Research Design & Development Production Sale Service Operation Decommission 11

12. Driving Innovation We are worlds 6 th largest manufacturer 12

13. Driving Innovation Products Production Processes Service Systems Value Systems The Four Pillars of the HVM Strategy The strategy includes key manufacturing activities that enhance competitive advantage in high wage economies; …and it recognises that large amounts of value-add and value- capture occur outside production – …and that technology may bring innovation in all areas. 13

14. Driving Innovation Prioritisation.. in areas of high growth + high R&D intensity Growth R&D Intensity 14

15. Driving Innovation High Value Manufacturing Competition The Step Change in Competitiveness / Value Systems Competition was launched in January 2009 and invited businesses in a broad range of industry sectors to form consortia and compete for funding. The aim was for companies to achieve major improvements of between 25% and 50% relative to their current performance in areas such as overall manufacturing costs, whole life-cycle costs, whole life environmental impact and product performance, durability and reliability. 15

16. Driving Innovation January 09 Competition - metrics £24M – Step Change in Competitiveness and Value Systems Your Response –500 downloads (enquiries) –300+ EoIs (>£300M investment requested) –87 Full Proposals assessed –32 projects shortlisted for funding 16

17. Driving Innovation And the results – how the £24m was won Sector/SIC GroupNumber of projects TSB funding (£m) TSB Funding (%) Bioscience & Healthcare139.138 Special Purpose Machinery84.920 Automotive33.415 Aerospace22.510 Electrical11.15 Non Ferrous Metals10.94 Construction20.83 Agrochemicals10.73 Environmental10.63 Total3224100 17

18. Driving Innovation Some of the Winning Consortia – here today at NESTA SHIELD Project Simon Collins Pete Ellison Tom Pinto Venu Kumar BIOCHEMIST Project Kay McClean CELL THERAPIES Project Tina Crombie HEPTACORE Project Mike Whelan RAPIDPART Project Russell Owen, Weir Valves Peter Brown, TWI STEP Project Keith Freebairn Professor Ian Sutherland 18

19. Driving Innovation Discussion Consortia members – you are our customers ! Customer satisfaction? How did you hear about the competition? Is the subject scope (technology) right for you? Funding and timescales? What do we (TSB & BIS) do right? What could we improve on? Other contributions & feedback? 19

20. Driving Innovation SHIELD Summary: The aim of project SHIELD is to develop novel acetabular and femoral components that minimise bone resorption. This will be achieved through a combination of component design and material optimisation by which the load transfer from prosthesis to bone will attempt to mimic bone stress levels pre-operation. The objective is to develop an innovative solution to the problem of stress shielding in hip implants therefore increasing the efficacy of total hip prostheses by increased life span and a reduced need for revision surgery after failed implantation. Partners: –Corin Ltd (lead), –Invibio Biomaterial Solutions Ltd, –Durham University –TWI Ltd, –Imorphics Ltd, –Continuum Blue Ltd. 20

21. Driving Innovation BIOCHEMIST Title: Biocatalysis and Chemical Engineering for Manufacturing Intensification and Sustainability - BIOCHEMIST Summary: This project will integrate all phases of bioprocess development from catalyst discovery and engineering, to process design, through to highly efficient small footprint manufacture of high value products - enhancing the efficiency, sustainability and flexibility of chemical manufacture. The principle objectives of the project are (a) a novel compact reactor system for efficient continuous chemical manufacture, (b) advanced process design to accelerate introduction of new bio-manufacturing processes and products (c) new competitive bioprocesses to prepare unnatural amino acids and chiral amines. Partners: –C -Tech Innovation Ltd (lead), –Ashe Morris Ltd, –Ingenza Ltd. 21

22. Driving Innovation STEP Title: Scalable Technology for the Extraction of Pharmaceuticals - STEP Summary: We plan to develop small footprint, versatile, counter-current chromatography purification technology and methodology which can be operated at a range of scales in both batch and continuous modes and that can be inserted into existing process plant and systems. The consortium will address major production challenges aiming to provide a flexible, low capital capability driving substantial cost efficiency in both drug development and drug manufacturing processes. Partners: –GlaxoSmithKline Research and Development Ltd (lead) –Brunel University –Pfizer Limited –Dynamic Extractions Ltd. 22

23. Driving Innovation MANUFACTURE OF CELL THERAPIES Title: Advanced manufacturing process for the production of individualised cell therapies Summary: Individualised cell therapies ("ICTs") for the treatment of cancer, autoimmune disease, and infectious disease are progressing through regulatory approval for clinical use. ICTs are generally based on natural or genetically enhanced immune cells with disease-fighting applications and are therefore distinct from regenerative stem cell therapies. This project aims to achieve the first advanced cell manufacturing system (the "CellPro Manufacturing System") to support the routine clinical use of ICTs on a cost- effective and convenient basis. Partners: –Cell Medica Ltd (lead) –University College London, –eXmoor pharma concepts ltd. 23

24. Driving Innovation RAPIDPART Title: RapidPart - Significant Step Change in the Selective Laser Melting Powder Bed Process for the Manufacture of High Value Components Summary: RapidPart will deliver step change reductions in the manufacturing cost of laser powder bed deposition, or Selective Laser Melting (SLM), by significantly increasing the speed of the process. The targeted 500% increase in processing speed will enable this high value, flexible and environmentally-friendly process to become commercially viable for a more widespread range of applications, giving the UK a technical advantage and world lead in laser additive manufacture. Partners: –Weir Valves and Controls UK Ltd (lead) –TWI Ltd (Academic) –Thinklaser Limited, –MTT Technologies Ltd, –SPI Lasers UK Limited – Disenco Limited, –Materialise UK. 24

25. Driving Innovation HEPTACORE Title: Commercial manufacture of a novel dual hepatitis vaccine (Hepatacore) Summary: The aim of this project is the further development and commercial manufacture of a tandem-core technology (TCT) vaccine candidate, such that a clinical trial may be undertaken. TCT allows the insertion of at least two different viral antigens into a single highly immunogenic recombinant protein. This results in a vaccine which can deliver immunity to two viruses simultaneously within the confines of a single construct. This project intends to manufacture commercially a combined hepatitis A and B vaccine (HAV/HBV). Partners: –iQur Ltd –University College London –Mologic Ltd. 25

26. Driving Innovation 26

27. Driving Innovation Helping you stay competitive Manufacturing Strategy –We believe our September 2008 HVM strategy (and the Governments Manufacturing Strategy published at the same time) remain valid and relevant, in recession and for recovery. Additional Funding –£150m Advanced Mfg package (July, Govt) –£5m extension to HVM competition (July, TSB) –£1m Technology Inspired Feasibility (Sept, TSB) –Further TSB competitions with significant manufacturing content planned for 2010. 27

28. Driving Innovation http://www.innovateuk.org e: robin.wilson@tsb.gov.uk t: 01793 442938 28