1. Medical Device Innovations Limited Daresbury Innovation Centre Daresbury International Science & Technology Park, Halton, Cheshire WA4 4FS www.mdi-md.com

2. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 2 Starting Position: The Clinical Need Invented by a practising radiologist Identified need for improved lubrication when placing radiological guidewires. The Clinical Need; failure to lubricate causes wire to stick = Risk to patient =Delay/abandonment of procedure = Waste of wire, waste of theatre time = Major cost implications MDi’s First Steps: Filed patent on wire lubricator device via United Bristol Healthcare Trust.

3. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 3 Inventor’s Original Concept Single Function: ‘Lubrication’ Extend usage Multiple functionality Patent Drawing

4. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 4 MDi Involvement Original Drawing Multiple functionality TORQUING PUSH

5. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 5 MDi Involvement Original Drawing Multiple functionality PLACEMENT PUSH

6. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 6 MDi Involvement Original Drawing Multiple functionality INTERNAL RESERVOIR

7. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 7 MDi Involvement Design & Development

8. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 8 MDi Involvement Design & Development

9. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 9 LubriTorqueTM – How it works... The Finished Article... Design & Development LubriTorque TM Next> Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] Stage 1

10. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 10 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 2 Push and lift with thumb LubriTorque TM

11. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 11 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 3 Part ‘Clicks’ Open LubriTorque TM

12. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 12 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 4 Hold part at both ends and rest over remaining fingers LubriTorque TM

13. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 13 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 5 Place wire across the centre of the part; no accuracy required LubriTorque TM

14. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 14 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 6 LubriTorque TM

15. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 15 The Finished Article... Design & Development Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] <Previous Next> LubriTorqueTM – How it works... Stage 7 The ‘V’ Guides will ensure the wire is correctly located LubriTorque TM

16. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 16 <Previous Next> Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] The Finished Article... Design & Development LubriTorqueTM – How it works... Stage 8 ‘Click’ closed LubriTorque TM

17. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 17 Stage: [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ][ 1 ][ 2 ][ 3 ][ 4 ][ 5 ][ 6 ][ 7 ][ 8 ][ 9 ] The Finished Article... Design & Development <Previous LubriTorqueTM – How it works... Stage 9 Process complete LubriTorque TM

18. © Medical Device Innovations Ltd. 2005 Our Innovations: LubriTorque TM Case Study 18 MDi Ltd. is currently in negotiations with several potential commercial partners, however enquiries from all interested parties would be welcome. Please contact: Martyn Collett, Business Development Director Email: mc@mdi-md.com Tel: 01925 607030