1. Cardiovascular System Hematology

2. Cardiovascular System

3. Connective Tissue: Blood Formed Elements [cells] Erythrocytes Leukocytes Platelets Ground Substance Fiber

4. Composition

5. Plasma Composition Function Hormone Control Problems

6. Plasma Proteins

7. Albumin Function

8. Blood Chemistries

9. Formed Elements of Blood

10. Blood Formation Pathways

11. Hematopoiesis Pluripotent Hematopoietic Stem Cell

12. Bone Marrow Smear

13. Red Bone Marrow

14. Red Bone Marrow Sampling

15. Hematopoietic Cell Lines

16. Blood Use

17. Erythropoiesis

18. EPO Source and MOA Juxtaglomerular Apparatus in Renal Cortex

19. Hemoglobin

20. Heme Group

21. Sickle Cell Anemia

22. Incomplete Dominance: SS, Ss, ss

23. Sickle Cell Anemia

24. Pernicious Anemia

25. Iron Deficiency Anemia

26. RBC Poikilocytosis

27. Hemoglobin Recycled

28. RBC Morphology and Function Size Shape Color Number Functions Gas Transport O2 CO2 Buffer

29. RBCs

31. Blood Tubes

32. Blood Smear Prep

33. Cytology Stains

34. Hematocrit

35. Hematocrit Equipment

36. RBC Problems: Anemia

37. RBC Problems: Parasites

38. Genetic Factors for Major Blood Types Blood Groups are due to CH20 on RBC surfaces Co-Dominant Inheritance pattern of alleles A, B, i Carbohydrates A allele  galactosamine B allele  galactose AB alleles  both sugars

39. ABO Antigen groups

40. Blood Type A: Subtypes A-1 A-2

41. Plasma Antibodies

43. Agglutinins & Agglutinogens

44. Agglutination

45. Blood Typing

46. Blood Typing Individual Results

47. Blood Typing Results Compared

48. Rh factor : D antigen

49. Blood Transfusion

50. Blood Donors and Recipients

51. WBCs

52. Leukocytes

53. WBC Development

54. Granulocytes and Agranulocytes

55. WBC percentages

56. Granulocytes

57. Granulocyte Formation

58. Granulocytes Neutrophils Eosinophils Basophils Nucleus Granules Size Number Function

59. RBM: Neutrophils

60. Neutrophils : PMNs

61. Neutrophil

62. PMN Comparison

63. “Old” Neutrophils

64. Eosinophil ID:

65. Eosinophils

66. Monocyte

67. Basophils

68. Basophil

69. Basophils in Animals

70. Mast Cells

71. Eosinophil and Basophil Compared

72. Neutrophil and Eosinophil Compared

73. Agranulocyte Formation

74. Agranulocytes Monocytes Lymphocytes Nucleus Cytoplasm Size Shape Number Function

75. Monocyte ID

76. Monocytes

77. Monocyte variations

78. Macrophages

79. WBC Cell Lines: Lymphoid

80. Lymphocytes

81. Lymphocyte

82. Agranulocytes Compared

83. WBC Summary

84. Diapedesis

85. Chemotaxis

86. WBC Defenses

87. WBC Differential Count 100 WBC Classify based on characteristics Compare to normal % Function of WBC Parameter changes Stress Viral Bacterial Parasitic

88. WBC count

89. Malaria trophozoite

90. Megakaryocyte

91. Platelet Formation

92. Platelets

93. Platelet Function

94. Platelet Function = Plug

95. Formed Element Summary

96. Lab Values: Hematology

97. Hemostasis Definition

98. Hemostasis Steps Vasoconstriction Platelet Plug Coagulation Fibrinolysis

99. Vascular Spasm

100. Platelet Plug Examples

101. Primary Hemostasis Phases

102. Platelet Receptors

103. Coagulation Overview

104. Clotting Proteins

105. Clotting Factors Numbered I – XII Most synthesized by liver Inactive until activated Some factors based on Vitamin K Ca++ required for most activation steps Found in the plasma

106. Pathways Intrinsic Extrinsic Common

107. Extrinsic Pathway of Coagulation

108. of Coagulation

109. Common Pathway of Coagulation Factor X  Xa Xa  Prothrombin Prothrombin  Thrombin Thrombin  Fibrinogen Fibrinogen  Fibrin-s Fibrin-s  Fibrin –i Clot stabilization

110. Fibrin Blood Clot

111. Fibrinolysis

112. Hemostasis Review

113. Coagulation Cascade

114. Clinical Tests and Monitoring

115. Blood Tests

116. Blood ID Practice

117. Summary

118. Immune Reactions

119. Other Blood Problems

120. Questions?