4. Hormones Secreted from anterior pituitary FSH and LH Bind to receptors located on the membrane of follicle cells FSH Development of oocyte in the follicle ( ovary) Thickening of follicle wall Secretion of follicular fluid Secretion of estrogen by follicle wall

5. More hormones LH Completion of meiosis in oocyte Partial digestion of the follicle wall allowing it to burst open (ovulation) Ovarian Hormones Estrogen Thickening of endometrium Blood vessel growth in endometrium Increase in FSH receptors in follicle Inhibition of FSH secretion and stimulation of LH secretion when estrogen levels are high.

6. Explain how hormones control the menstrual cycle in human females. (Total 8 marks)

7. FSH stimulates the development of follicles; FSH stimulates estrogen secretion (by the developing follicle); estrogen stimulates the repair of the uterus lining; estrogen stimulates LH secretion; LH causes ovulation; LH causes the development of the corpus luteum; LH causes secretion of progesterone; progesterone causes thickening of the uterus lining / prepares uterine lining for implantation; progesterone / estrogen inhibits the secretion of LH / FSH; falling progesterone levels at the end of the cycle allow FSH production / menstruation; feedback control;8 max

8. Hormones Progesterone Maintenance of thickening of the endometrium with many blood vessels Inhibition of FSH and LH secretion

14. Outline the process of in vitro fertilization (IVF). (Total 6 marks)

15. (IVF) is fertilization outside body / "in glass"; (drug) stops normal menstrual cycle; (inject FSH) to stimulate ovaries / stimulate production of eggs; (HCG) matures the follicles; eggs are removed from follicles / ovaries / mother; male provides sperm / sperm donor; washing / capacitation of sperm; eggs are mixed with sperm; 2–3 embryos are implanted into uterus; pregnancy test is done to see if implantation / pregnancy has occurred; [6]

16. Discuss the ethical issues of in vitro fertilisation (IVF) in humans. (8)

17. Arguments against (IVF): fertilized egg has potential to become a person / some view a fertilized egg as having special status; IVF requires the production of multiple embryos; fate of extra embryos is ethical concern; ethics of long-term storage; stem-cell research is blurring issue as other cells now have the possibility of becoming a person; procedure may result in multi-embryo pregnancy which places stress on the family resources / unwanted children; issues of equity of access / expensive; high rates of failure; ownership / responsibility for stored embryos an issue; religious opposition / playing God;

18. Arguments favouring (IVF): only way some couples can have children / helps infertile couples; allows for genetic screening; allows for surrogate mothers;8 max For full marks at least two of the points should include the counter-argument, otherwise [6 max].

19. Spermatogenesis

20. Oogensis

27. Describe the structure and function of the placenta. (Total 6 marks)

28. structure: [3 max] placenta is composed of fetal and maternal tissues; villi increase surface area; vascularization / capillaries within placental villi; intervillous spaces through which maternal blood flows; function: [4 max] secretes estrogen to maintain uterine lining; secretes progesterone to maintain uterine lining; gas / nutrient exchange for fetus; removes waste products; acquiring passive immunity / antibodies cross placenta; secretes HCG; [6]