1. N E U R O A N A L Y S I S neuroanalysis.org.il

2. Doctor, I am depressed, and sad. What do I have, doctor? Please tell me. You have depression.

3. Doctor, my stomach hurts. What do I have, doctor ? Please tell me. You have gastritis. Doctor, I am depressed, and sad. What do I have, doctor? Please tell me. You have depression.

4. Doctor, my stomach hurts. What do I have, doctor? Please tell me Doctor, I am depressed, and sad. What do I have, doctor ? Please tell me. You have depression. ? ? ? Place in the body What happened to it? It is infected How to treat it Antibiotics You have gastritis.

5. …. “we are at the epicycle stage of psychiatry where astronomy was before Copernicus and biology before Darwin”…. Allen Frances

6. Neuroscience NeuroAnalysis Rational

7. Neuroscience Phenomenology NeuroAnalysis Rational

8. Neuroscience Phenomenology Enormous gap The clinician sees a patient not neuronal networks or neurotransmitters NeuroAnalysis Rational

9. Neuroscience Phenomenology Enormous gap The clinician sees a patient not neuronal networks or neurotransmitters NeuroAnalysis Rational

10. Why we failed ? Neuroscience Phenomenology NeuroAnalysis Rational

11. Why we failed ? NeuroAnalysis Rational

12. Where did we fail? Ignoring complexity NeuroAnalysis Rational

13. Proposed RDoC NeuroAnalysis Rational

14. Clinical Brain Profiling CBP NeuroAnalysis Rational

15. Clinical Brain Profiling CBP Explanatory power NeuroAnalysis Rational

16. Clinical Brain Profiling CBP For example DISC1 NeuroAnalysis Rational

17. Clinical Brain Profiling CBP Future intervention power cure Optogenetics NeuroAnalysis Rational

18. Clinical Brain Profiling CBP Translation matrix NeuroAnalysis Rational

19. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN NeuroAnalysis Rational

20. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN NeuroAnalysis Rational

21. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN Psychosis Disconnection Syndrome NeuroAnalysis Rational

22. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN NeuroAnalysis Rational

23. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN Clinical Brain Profiling CBP NeuroAnalysis Rational

24. Neuroscience Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN Clinical Brain Profiling CBP Based on Literature Publications Based on Neural network simulations Based on 20 years of theoretical work NeuroAnalysis Rational

25. Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN Clinical Brain Profiling CBP Predicted disturbance CF(b) = 2 DMN =5 Cs =10 Ci =3 Hbu =7 Htd =1 D = 13 O =0 CF =5 NeuroAnalysis Rational

26. NeuroAnalysis Validation How to detect, diagnose & monitorNetwork disturbances Clinical phenomena Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity, Free energy estimations, Entropy measurements integrated information theory Disturbances to development of default mode network Personality disorders Short-term over time Dynamics of Matching complexity, Free energy estimations, Entropy measurements integrated information theory Disturbances to Optimization dynamics Mood & Anxiety Small world network analysis for hub composition, Estimating hierarchy, k-shell decomposition percolation theory and fractal geometry Hierarchal (top-down bottom-up) disorders Schizophrenia delusions and abolition Correlations, Synchrony, Granger causality, Mutual information, Dimension estimation, Bayesian statistics Dynamic Causal Modeling, Independent components analysis Neural complexity (Correlation matrix), overall Small world network analysis Connectivity imbalances Disconnection over- connection Schizophrenia Disorganization deficiency

27. Cardiac Insufficiency Brain Insufficiency Diagnose Algorithm of Disturbance Correct with Pacemaker Algorithm of Disturbance Correct with Brain Pacemaker

28. Cardiac Insufficiency Brain Insufficiency Diagnose Algorithm of Disturbance Correct with Pacemaker Algorithm of Disturbance Correct with Brain Pacemaker Phenomenology Brain disturbance

29. Brain Insufficiency Cardiac Insufficiency Diagnose Algorithm of Disturbance Correct with Pacemaker Algorithm of Disturbance Correct with Brain Pacemaker Clinical Brain Profiling CBP

30. N E U R O A N A L Y S I S neuroanalysis.org.il

31. N E U R O A N A L Y S I S neuroanalysis.org.il