Download presentation

Presentation is loading. Please wait.

1
**Bayesian models for fMRI data**

Klaas Enno Stephan Translational Neuromodeling Unit (TNU) Institute for Biomedical Engineering, University of Zurich & ETH Zurich Laboratory for Social & Neural Systems Research (SNS), University of Zurich Wellcome Trust Centre for Neuroimaging, University College London With many thanks for slides & images to: FIL Methods group, particularly Guillaume Flandin and Jean Daunizeau The Reverend Thomas Bayes ( ) SPM Course Zurich 13-15 February 2013

3
**Bayes‘ Theorem Posterior Likelihood Prior Evidence**

Reverend Thomas Bayes “Bayes‘ Theorem describes, how an ideally rational person processes information." Wikipedia

4
Bayes’ Theorem Given data y and parameters , the joint probability is: Eliminating p(y,) gives Bayes’ rule: Likelihood Prior Posterior Evidence

5
**Bayesian inference: an animation**

6
**Principles of Bayesian inference**

Formulation of a generative model likelihood p(y|) prior distribution p() Observation of data y Update of beliefs based upon observations, given a prior state of knowledge

7
**Posterior mean & variance of univariate Gaussians**

Likelihood & Prior Posterior Posterior: Likelihood Prior Posterior mean = variance-weighted combination of prior mean and data mean

8
**Same thing – but expressed as precision weighting**

Likelihood & prior Posterior Posterior: Likelihood Prior Relative precision weighting

9
**Same thing – but explicit hierarchical perspective**

Likelihood & Prior Posterior Posterior Likelihood Prior Relative precision weighting

10
** Why should I know about Bayesian stats?**

Because Bayesian principles are fundamental for statistical inference in general sophisticated analyses of (neuronal) systems contemporary theories of brain function

11
**Problems of classical (frequentist) statistics**

p-value: probability of observing data in the effect’s absence Limitations: One can never accept the null hypothesis Given enough data, one can always demonstrate a significant effect Correction for multiple comparisons necessary Solution: infer posterior probability of the effect

12
**posterior distribution**

Generative models: Forward and inverse problems forward problem likelihood prior inverse problem posterior distribution

13
**Dynamic causal modeling (DCM)**

EEG, MEG fMRI Forward model: Predicting measured activity given a putative neuronal state Model inversion: Estimating neuronal mechanisms from brain activity measures Friston et al. (2003) NeuroImage

14
**sensations – predictions**

The Bayesian brain hypothesis & free-energy principle sensations – predictions Prediction error Change sensory input Change predictions Action Perception Maximizing the evidence (of the brain's generative model) = minimizing the surprise about the data (sensory inputs). Friston et al. 2006, J Physiol Paris

15
**Individual hierarchical Bayesian learning**

volatility associations events in the world sensory stimuli Mathys et al. 2011, Front. Hum. Neurosci.

16
**Aberrant Bayesian message passing in schizophrenia: **

abnormal (precision-weighted) prediction errors abnormal modulation of NMDAR-dependent synaptic plasticity at forward connections of cortical hierarchies Backward & lateral input Forward & lateral g: generative model : expectation of approximate recognition density : parameters of generative model (= connection strengths between levels) : hyperparameters (= parameters encoding the uncertainty of the approximate recognition model) : prediction error Forward recognition effects De-correlating lateral interactions Backward generation effects Lateral interactions mediating priors Stephan et al. 2006, Biol. Psychiatry

17
** Why should I know about Bayesian stats?**

Because SPM is getting more and more Bayesian: Segmentation & spatial normalisation Posterior probability maps (PPMs) 1st level: specific spatial priors 2nd level: global spatial priors Dynamic Causal Modelling (DCM) Bayesian Model Selection (BMS) EEG: source reconstruction

18
**Bayesian segmentation Posterior probability**

and normalisation Spatial priors on activation extent Posterior probability maps (PPMs) Dynamic Causal Modelling Image time-series Statistical parametric map (SPM) Kernel Design matrix Realignment Smoothing General linear model Statistical inference Gaussian field theory Normalisation p <0.05 Template Parameter estimates

19
**Spatial normalisation: Bayesian regularisation**

Deformations consist of a linear combination of smooth basis functions (3D DCT). Find maximum a posteriori (MAP) estimates: Deformation parameters MAP: “Difference” between template and source image Squared distance between parameters and their expected values (regularisation)

20
**Spatial normalisation: overfitting**

Affine registration. (2 = 472.1) Template image Non-linear registration without regularisation. (2 = 287.3) Non-linear registration using regularisation. (2 = 302.7)

21
**Bayesian segmentation with empirical priors**

Goal: for each voxel, compute probability that it belongs to a particular tissue type, given its intensity Likelihood: Intensities are modelled by a mixture of Gaussian distributions representing different tissue classes (e.g. GM, WM, CSF). Priors: obtained from tissue probability maps (segmented images of 151 subjects). p (tissue | intensity) p (intensity | tissue) ∙ p (tissue) Ashburner & Friston 2005, NeuroImage

22
**Bayesian fMRI analyses**

General Linear Model: with What are the priors? In “classical” SPM, no priors (= “flat” priors) Full Bayes: priors are predefined Empirical Bayes: priors are estimated from the data, assuming a hierarchical generative model Parameters of one level = priors for distribution of parameters at lower level Parameters and hyperparameters at each level can be estimated using EM

23
**Posterior Probability Maps (PPMs)**

Posterior distribution: probability of the effect given the data mean: size of effect precision: variability Posterior probability map: images of the probability that an activation exceeds some specified threshold, given the data y Two thresholds: activation threshold : percentage of whole brain mean signal probability that voxels must exceed to be displayed (e.g. 95%)

24
**2nd level PPMs with global priors**

1st level (GLM): 2nd level (shrinkage prior): Heuristically: use the variance of mean-corrected activity over voxels as prior variance of at any particular voxel. (1) reflects regionally specific effects assume that it is zero on average over voxels variance of this prior is implicitly estimated by estimating (2) In the absence of evidence to the contrary, parameters will shrink to zero.

25
**2nd level PPMs with global priors**

1st level (GLM): voxel-specific 2nd level (shrinkage prior): global pooled estimate over voxels Compute Cε and C via ReML/EM, and apply the usual rule for computing posterior mean & covariance for Gaussians: Friston & Penny 2003, NeuroImage

26
**PPMs vs. SPMs PPMs Posterior Likelihood Prior SPMs Bayesian test:**

Classical t-test:

27
**PPMs and multiple comparisons**

Friston & Penny (2003): No need to correct for multiple comparisons: Thresholding a PPM at 95% confidence: in every voxel, the posterior probability of an activation is 95%. At most, 5% of the voxels identified could have activations less than . Independent of the search volume, thresholding a PPM thus puts an upper bound on the false discovery rate. NB: being debated

28
**PPMs vs.SPMs PPMs: Show activations greater than a given size**

SPMs: Show voxels with non-zero activations

29
**PPMs: pros and cons Advantages Disadvantages**

One can infer that a cause did not elicit a response Inference is independent of search volume do not conflate effect-size and effect-variability Estimating priors over voxels is computationally demanding Practical benefits are yet to be established Thresholds other than zero require justification

30
**Model comparison and selection**

Given competing hypotheses on structure & functional mechanisms of a system, which model is the best? Pitt & Miyung (2002) TICS Which model represents the best balance between model fit and model complexity? For which model m does p(y|m) become maximal?

31
**Bayesian model selection (BMS)**

Model evidence: Gharamani, 2004 p(y|m) y all possible datasets accounts for both accuracy and complexity of the model Various approximations, e.g.: negative free energy, AIC, BIC a measure of generalizability McKay 1992, Neural Comput. Penny et al. 2004a, NeuroImage

32
**Approximations to the model evidence**

Logarithm is a monotonic function Maximizing log model evidence = Maximizing model evidence Log model evidence = balance between fit and complexity No. of parameters In SPM2 & SPM5, interface offers 2 approximations: No. of data points Akaike Information Criterion: Bayesian Information Criterion: Penny et al. 2004a, NeuroImage

33
**The (negative) free energy approximation**

Under Gaussian assumptions about the posterior (Laplace approximation):

34
**The complexity term in F**

In contrast to AIC & BIC, the complexity term of the negative free energy F accounts for parameter interdependencies. The complexity term of F is higher the more independent the prior parameters ( effective DFs) the more dependent the posterior parameters the more the posterior mean deviates from the prior mean NB: Since SPM8, only F is used for model selection !

35
Bayes factors To compare two models, we could just compare their log evidences. But: the log evidence is just some number – not very intuitive! A more intuitive interpretation of model comparisons is made possible by Bayes factors: positive value, [0;[ B12 p(m1|y) Evidence 1 to 3 50-75% weak 3 to 20 75-95% positive 20 to 150 95-99% strong 150 99% Very strong Kass & Raftery classification: Kass & Raftery 1995, J. Am. Stat. Assoc.

36
**BMS in SPM8: an example M1 M2 M3 M4 attention PPC PPC BF 2966**

M2 better than M1 attention stim V1 V5 stim V1 V5 M1 M2 M3 M4 V1 V5 stim PPC M3 attention M3 better than M2 BF 12 F = 2.450 Posterior model probability in lower plot is a normalised probability: p(m_i|y) = p(y|m_i)/sum(p(y|m_i)) Note that under flat model priors p(m_i|y) = p(y|m_i) V1 V5 stim PPC M4 attention M4 better than M3 BF 23 F = 3.144

37
Thank you

Similar presentations

Presentation is loading. Please wait....

OK

Bayesian models for fMRI data

Bayesian models for fMRI data

© 2017 SlidePlayer.com Inc.

All rights reserved.

Ads by Google

Ppt on synthesis and degradation of purines and pyrimidines rings Ppt on deforestation in india Download ppt on live line maintenance tools A ppt on loch ness monster found Ppt on pre ignition curve Ppt on panel discussion panelists Ppt on the rise of nationalism in europe class 10 Ppt on ufo and aliens in california Ppt on computer viruses and worms Ppt on induced abortion