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The sparks and the soup I wonder whether anybody during my few remaining years will yet discover either of the (probably) two missing transmitters.

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Presentation on theme: "The sparks and the soup I wonder whether anybody during my few remaining years will yet discover either of the (probably) two missing transmitters."— Presentation transcript:

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3 The sparks and the soup

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5 I wonder whether anybody during my few remaining years will yet discover either of the (probably) two missing transmitters concerned in your monosynaptic excitatory and inhibitory effects on different motoneurones. Dale to Eccles, October 1, 1953

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7 tyrosineDOPA dopaminenoradrenaline Biosynthetic pathway for noradrenaline

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14 Hans Corrodi,

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16 A New Concept (1970s): Medicinal chemistry and pharmacology Under the same roof In academic setting

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18 High Low Normal Psychomotor activation Dopamine stabilizer High Low Normal Psychomotor activation Standard antipsychotic Dopamine Stabilizers

19 n-Pr SO 2 CH 3 N H Structure of (-)-OSU6162

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21 Future Vision: Restart Our Drug Research According to the Previous Concept Supported by The Arvid Carlsson Fund


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