1. L A B O R A T O R I E S O F A M E R I C A Emerging Technology Opportunities in Health and Wellness- From Potential to Product Deepak Ayyagari, PhD Principal Scientist, Sharp Labs of America Secretary, Continua Health Alliance September 25, 2007

2. L A B O R A T O R I E S O F A M E R I C A A history of "firsts" 19121915 Tokuji Hayakawa invents the Ever-Sharp Pencil. 1925 Assembly and marketing of crystal radio sets. 1953 Mass production of TV sets to coincide with Japan's first TV broadcasts. 1960 Mass production of color TV sets. Color TV broadcasting begins in Japan. Sharp's founder, Tokuji Hayakawa, establishes a metal works in Tokyo. Sharp History -1

3. L A B O R A T O R I E S O F A M E R I C A 19621963 1964 Development and mass production of the world's first all-transistor desktop calculator. Mass production of solar cells and silicon-based photovoltaic cells. Mass production of microwave ovens. 1969 Development of ELSI chips. Marketing of electronic calculators incorporating ELSIs. 1970 Akira Saeki becomes president. Changes name from Hayakawa Electric Industry Co. to Sharp Corporation. Sharp History- 2

4. L A B O R A T O R I E S O F A M E R I C A 1973 Development of the world's first COS electronic calculator incorporating an LCD. 1979 Development and introduction of the world's first super-thin 1.6-mm card-sized calculator. 1981 Development of the world's first long- life laser diode. 1982 Introduction of the world's first combination PC/TV set. Sharp History- 3

5. L A B O R A T O R I E S O F A M E R I C A 19861987 1988 19891990 Development of an electronic organizer with multiple functions. Development of the world's first 14-inch large- screen, thin- profile, high- definition color TFT LCD unit. Introduction of 100-inch LCD projectors that can be carried from room to room. Introduction of a home copier/ facsimile. Haruo Tsuji becomes president. Sharp History -4

6. L A B O R A T O R I E S O F A M E R I C A 1992 Development and introduction of an HDTV with simplified MUSE decoder. 1993 Development and introduction of an all-in-one Personal Information Tool for business use. 1996 Development and introduction of the world's first LCD Viewcam. Introduction of a fully automatic washing machine with hole-less tub that saves water and detergent by 30%. Introduction of an Internet- ready color LCD notebook PC, equipped with a vivid, clear LCD screen offering 30% greater brightness. Development and introduction of an Internet-ready Color Personal Information Tool that can gather, create and send information, sound and images in color. Sharp History- 5

7. L A B O R A T O R I E S O F A M E R I C A Development of a reflective-type Super- Mobile TFT LCD, which displays 260,000 colors in amazing clarity even in direct sunlight and with no backlight. 1997 1998 2000 Development of the world's first Plasmacluster TM Ion air purification technology that's effective against airborne mold. Introduction of an ultra- thin, ultra-light, B5-file size notebook PC with a large 11.3-inch TFT color LCD. Katsuhiko Machida becomes president. Sharp History- 6

8. L A B O R A T O R I E S O F A M E R I C A 2001 20022003 Introduction of the world's first 37V*-inch LCD TV with a built-in terrestrial digital HDTV tuner. Introduction of a 30V*-inch high-definition LCD TV with built-in digital BS HDTV tuner. Development and introduction of the world's lightest and thinnest notebook PC with a 12.1-inch LCD. * All screen sizes are measured diagonally. Development of a revolutionary 3D display technology that provides a realistic sense of depth and presence. Sharp History - 7

9. L A B O R A T O R I E S O F A M E R I C A Consumer Driven Change 1960s 2005 Heat Food Reduce Fat Conserve Polyphenols Conserve Energy … Consumer Consciousness Health Awareness Energy Awareness

10. L A B O R A T O R I E S O F A M E R I C A Anywhere, Anytime Personal Health Technologies and Services Home Mobile Foods (calories) Health check MFP Blood pressure Blood oxygen, Heart beat Sleeping Ring sensor Hospital & Medical network (Doctors, Inspection, Treatment, Medication Implant sensor Diet Monitoring Allergen detection

11. L A B O R A T O R I E S O F A M E R I C A Analyzing new opportunities- A process Idea/Concept Technology Market Business Fit Value Calculus Decisions Product Development Intent Clarity Consumer Need Regulation- Market Regulation- Product Interoperability/Stds. +/- Misc. +/- Revenue Model +/-

12. L A B O R A T O R I E S O F A M E R I C A Personal Healthcare Opportunities - An evaluation Idea/Concept Technology Market Business Fit Value Calculus Decisions Product Development Intent Clarity Consumer Need Regulation- Market Regulation- Product Interoperability/Stds. ++ +/? ?? Misc. ?? + + + Revenue Model ??

13. L A B O R A T O R I E S O F A M E R I C A Continua the Panacea? Interoperability Reimbursement Test, Cert & Logo Regulation Out of Box Operation Performance Guarantees Ease of Use Simple Messaging Consumer Centric Use Cases CONTINUA Chronic Disease Management Aging Independently Wellness and Fitness Standards Selection Technical Guidelines Inter-op Specs. Definition of Reg. Pathways for PHD Geo Specific Who pays? how much ? Geo specific 2008 Logo program Launch T&C Program Launch 2008 V1 Guidelines Release 2008 Work with Regulatory Agencies 2008 Reimbursement Strategies

14. L A B O R A T O R I E S O F A M E R I C A Imponderables Patient Centric Healthcare-Model of Future? Where are the economic incentives to keeping people healthy? What is the patient really capable of? Social factors far outweigh technology capabilities? True empowerment or lip service? Practice meets dreamscape? Changes in Doctoring- whither? Cost and the Methodology of Care With level of service/outcomes at least as good as current SOC, find the cheapest way to provide care => Call to regulators and policy makers.