1. New and ongoing areas of research In the EuroQol Group

2. New research International 5L valuation –Discussed already EQ-5D-Y –Youth version Disease specific adaptations –‘Bolt on’ additional dimensions

3. EQ-5D-Y: Youth

4. Translations –Available in more than 20 languages –Youth between 7-12 years Proxy versions –In development

5. Administration seems OK

6. But not yet a value set How should value the health states –Children? –Parents? –The general public? How do you include: –Development backlog? –The remarkable coping skills children?

7. Are values different Do we value health states different? –For ourselves –For someone other like ourselves –For a 10-year child New paper of the 2012 Meeting

8. Values for children 10% lower

9. Feedback from the 2012 meeting Small number of health states Still VAS –Does this also apply for TTO? –Complication: How to apply TTO for health states of children? Descriptive system EQ-5d-Y is different!

10. Bolt-on Do we miss dimensions? In the past: EQ-6D –Mobility; –Daily activity and self care; –Work performance –Family and leisure performance –Pain/discomfort –Present mood First attempts –EQ-5D+cog: addition of cognition?

11. EQ-5D+cog Used in DALY WHO project –Cognition was recognized as important Lot of discussion –Is it necessary? –Who is making the value set? –An unofficial set exist Based on mapping DALY project Is used… –But gives confusion No official status

12. Why not other dimensions? Developed already –Psoriasis –Vision

13. VF-14 by Visual acuity in macular degeneration

14. EQ-5D by Visual acuity in macular degeneration

15. Evidence on EQ-5D: some examples Hearing Schizophrenia Bipolar disorder Vision Depression and anxiety Some cancers Skin Personality disorder

16. Psoriasis

17. Estimation of utilities Used standard EQ-5D-3L TTO protocol General public interviews in UK only –N = 300 Sub-set of 49 states were included using orthogonal design

18. Results OLS and random effects models estimated –Interaction terms; collapsing levels Both dimensions have a significant impact Some inconsistencies in the data The largest gap is between level 3 and 4 (moderate and severe)

19. Modeling TTO values Psoriasis

20. Discussion 2012 meeting No real problem when seen as pilot –Convenience sample –TTO not standardised Methodological complications –Things get complicated for responders fast 223451 versus 122345 Cognition overload –5 7 = 78.125 health states Similar values for 4 th and 5 th levels Modeling stressed to the limit?