1. Medical Image Resource Center

2. What is MIRC? Medical Image Resource Center Makes it easier to locate and share electronic medical images and related information –On your PC –In your Department –Throughout the world

3. MIRC: Why? MIRC can help: –Teaching and decision support in clinical patient care –Clinical trials –Make research databases more freely available to the imaging community

4. The Evolution of MIRC Originally conceived as a large centralized database of images and related clinical information

5. The Evolution of MIRC Originally conceived as a large centralized database of images and related clinical information It soon become clear to us that a more effective strategy would be to: Create a standard that would tie together virtual communities of new and existing medical image libraries

6. Key MIRC Concepts Libraries cooperate by supporting a common query mechanism A Query mechanism allows users to find information within these libraries MIRC supports multiple information storage formats

7. Key MIRC Concepts Libraries cooperate by supporting a common query mechanism A Query mechanism allows users to find information within these libraries MIRC supports multiple information storage formats

8. Key MIRC Concepts Libraries cooperate by supporting a common query mechanism A Query mechanism allows users to find information within these libraries MIRC supports multiple information storage formats

9. MIRC Libraries MIRC libraries archive a wide variety of text, images, and other multimedia information –Teaching files –Research and reference image repositories Collection of disease specific radiographs Normal variants Functional brain MR data sets Clinical trials images and related data Journal articles Textbooks PowerPoint and other types of presentations

10. MIRC Components Query Service Entry point into the MIRC community for a user on the Internet, Query service can be created by site using the MIRC query schema.

11. MIRC Components Storage Service: Cooperating information library – a web archive or a database, designed to support the MIRC query mechanism. Index: The librarys card catalog – an XML document that identifies content of a storage service. Server: The librarys shelves – where the content of a MIRC site is stored or saved.

12. The MIRC Community Internet Server Index MIRC Sites Server Index RSNA User Server Index MIRC Storage Service: - Document Authoring - Document Storage - Document Indexing - Web Server MIRC Query Service: - Access to the community

13. MIRC Query Service: User Fills in Query Form

14. MIRC Query Results: Displays Hits from MIRC Sites

15. MIRC Teaching File Display: MIRC-TF Display Formats

16. MIRC Authoring Tools New Authoring Tool

17. MIRC Authoring Tools Image Annotation

18. MIRC Clinical Trials Features Image acquisition from modalities and PACS Image and metadata anonymization Secure image and metadata transport Automatic storage and indexing of all data, with the standard MIRC search and display functions Interfacing to external databases for trial- specific analysis

19. FC DICOM FC DICOM FC DICOM PI DICOM PI DICOM MIRC Clinical Trial Configuration Modalities MIRC FieldCenter Application: - Image reception - Anonymization - Transmission to PI Workstations MIRC Site: - Image reception - Image Storage - Transfer to PACS and/or workstations Firewalls Internet HTTP HTTPS

20. MIRC in Clinical Trials MIRC currently only non-proprietary software/standard available free and open source for clinical trials After extensive evaluation of the software, the National Cancer Institutes Cancer Imaging Program has selected MIRCs free and open source clinical trials software suite for use in clinical trials

21. Other Ongoing Clinical Trials WHIMS 1-3 ( Women's Health Initiative Memory Study) WHI – Womens Health Initiative CT Study CARDIA - Coronary Artery Risk Development in Young Adults RIDER - Reference Image Database to Evaluate Response to Therapy CIREN – Crash Injury Research & Engineering Network –Wake Forest (PI) CAMPS – Carotid Atherosclerosis MRI Progression Study –University of Washington (PI)

22. Research Dataset Acquisition MIRC feature developed with Mallinckrodt Institute of Radiology Allows internal researchers to acquire DICOM images from modalities, store and manage them without using the clinical PACS –Bridges internal networks –Tracks access of PHI for HIPAA compliance

23. NCI Collaboration Successful demonstration in early 2005 Support of current trials (RIDER, LIDC) Decision to use MIRC for clinical trials in the future Development of MIRC extensions to support the NCI imaging database

24. Field Centers at Remote Clinical Sites Firewall De-ID MIRC Field Center Firewall De-ID MIRC Field Center Firewall De-ID MIRC Field Center DICOM HTTP HTTPS Submission MIRC Storage Service MIRC DICOM Service MIRC Database Service Firewall MIRC I3 DB (Annotations: Image, Clinical, Markup, etc.) Hibernate (I3 ORM) I3 Object API caCORE SDK Data Manager Curation Data Manager CSM API Processors Query, Result set, User Registration, Lookup Manager, CSM, Export Data Transfer Object (DTO) Java Server Faces (JSF) Cancer Centers Researchers Academia Industry Hibernate (CSM) Hibernate (I3 ORM) Data Access Layer HTTP FTP MDB Image zipping File System (DICOM, XML, DOC) JBoss Tomcat Retrieval

25. Open Source Project All source code is available on-line –Zip archive through the RSNA MIRC site –CVS repository Actively maintained MIRC project list

26. MIRC User Group Meetings Monday 1:30-3:00 E262 Thursday 12:30-2:30 E257

27. How to Participate? Use MIRC to perform searches for images and information Be an author Set up a MIRC site: –Connect your existing Teaching File system –Build your own Teaching File system: Use the RSNA MIRC Site implementation Use someone elses Come up with your own and make it MIRC compatible

28. Need More Information? Go to http://mirc.rsna.org There is a link to Downloads where you can find all the documents, software and installation instructions for setting up a MIRC site and creating content.