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Cell Cycle Regulation & Cancer
Normal Cell Cycle Cyclins: proteinsCDKs (Cyclin dependent kinases): enzymes Cyclins and CDKs bind together to activate parts of the cell cycle
Normal Cell Cycle G1 checkpoint G2 checkpoint M checkpointIf something is wrong, cycle will STOP
ABNormal Cell Cycle CANCER: when cell cycle regulations failCrowd out normal cells Spend less time in Interphase
ABNormal Cell Cycle Apoptosis:cell death( if damaged)Cancer: no apoptosis
Tumor: MASS OF CANCER CELLSTWO TYPES OF TUMORS Benign: stays contained Malignant: spread to nearby tissue or other organs
Why are Tumors bad? Angiogenesis: when tumors get a blood supplynutrients and oxygen go to tumor
Why are Tumors bad? Metastasis: pieces of tumor travel through blood to other organs
Causes of cancer Gene Mutations: changes in genes that control cell cycle What causes these mutations?
Cancer causes Carcinogens: cancer causing substancesEX: tobacco smoke, asbestos Radiation EX: UV light from sun, X-rays
Cancer causes Virus EX: Human Papilloma Virus (HPV) HereditaryEX: breast Sporadic (no reason)
Treatments Prevention!!!!!Diet, exercise, healthy weight, no smoking, limit alcohol Screenings Catch it early! Mammograms Pap smear Colonoscopy
Treatments Surgery Remove tumor and surrounding tissue RadiationDirectly kill tumor Chemotherapy Drug treatment
Incidence Rates: Male (From CDC) Female
Death Rates: Male Female
Mitosis & Cancer: When Making New Cells Goes Terribly Wrong!
What is it? Treatment options Prevention. Disease Cells grow and divide uncontrollably No way to stop Damage to body around them.
Ch. 9.3 – Cell Cycle Regulation
Cancer. Cancer is one of the most common diseases in the developed world: 1 in 4 deaths are due to cancer 1 in 17 deaths are due to lung cancer Lung cancer.
Cancer Cells Gone Wild!. Cancer Cell Surrounded by T-cells and dead.
Cancer Facts -a growth of abnormal cells -grow and invade healthy tissue -2 nd leading cause of death in U.S -1/2 of all males in U.S develop cancer -1/3.
Cancer is the 2 nd leading cause of death in the United States Cancer is uncontrolled abnormal cell growth. It can occur on the skin, body tissue, bone.
Another way to think of cancer is “Mitosis Run Amok.”
What is cancer? Is it contagious?
10.3 Regulating the Cell Cycle
Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings.
AP Biology Regulation of Cell Division.
Control of the Cell Cycle. Cyclins Cell cycle is controlled by proteins called cyclins and a set of enzymes that attach to the cyclin and become activated.
KEY CONCEPT Cell cycle regulation is necessary for healthy growth.
Cell Cycle Regulation Chapter 9 Section 3.
Cell Cycle and Cancer.
Cell Division Gone Wrong
Section 10.3 (Pg ): Regulating the Cell Cycle
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