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Bryan Sloane Trauma Research Associate Program 2010.

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Presentation on theme: "Bryan Sloane Trauma Research Associate Program 2010."— Presentation transcript:

1 Bryan Sloane Trauma Research Associate Program 2010


3  Also more commonly known as a Concussion  Differs from Cerebral Contusion  Very common in contact sports  Acute but transient effects  Emotional, physical and cognitive effects  Frequent MTBIs can add to each other, causing cumulative brain damage  Loss of brain function, similar to a petite mal Sz

4  Injury to a portion of the brain resulting from rapid acceleration or deceleration of the brain  Impact against the skull causes edema and loss of functionality Damage can last from hours to weeks Neurotransmitters released in excess as a result of injury (mechanical depolarization) ->Causes deregulation of membrane potential and unfocused depolarization -> ATPase pumps (Na/K) work in excess to restore balance ->Cells become hypermetabolic, and Glucose levels can be depleted. Decreased cerebral blood flow adds to this effect and can create long lasting damage. Axonal damage can occur due to stretching or sheering of the neuronal Axons when they experience the force (DIA)

5  Confusion/ disorientation/ amnesia/ emotional changes  LOC  Headache, Dizziness, vomiting, nausea  Lack of motor coordination  Audio/visual disturbances  Tinnitus  Convulsions

6  MTBI can be broken down into three categories as defined by the American Academy of Neurology Guidelines  Grade I  Confusion, no LOC and symptoms last less than 15 mins  Grade II  Confusion and disorientation with symptoms lasting more than 15 mins  Grade III Loss of Consciousness  IIIa LOC lasts seconds  IIIb LOC last for minutes  EEGs obtained after concussive injury in animal models show the same electrical activity as generalized Sz activity (confusion is similar to post- ictal state after a Sz)  Clinically measured using Glasgow Coma Scale and A&Ox4 questions  Person, Place, Time, Event

7  MTBI usually presents with high GCS  Confusion and disorientation could present at 14

8  Mortality is very low, but repeated MTBI can cause long term damage with the injury increasing in severity with each successive incident  Most of the time observation and non ASA analgesics are used.  Trauma patients are frequently observed until other factors that could mask a more severe Brain Injury wear off (sedation, drugs, EtOH)  Most of the time there are no structural changes visible on a head CT.

9  Cumulative effects  Increased risk of Alzheimer’s disease and memory problems  Second-impact syndrome  Fatal in many cases  Occurs when a second minor blow to the head is experienced after a recent MTBI  Could be due to Blood Vessels in the brain losing the ability to regulate blood flow and ICP rapidly increases.

10  Of the 1.4 million who sustain a TBI each year in the United States:  50,000 die;  235,000 are hospitalized; and  1.1 million are treated and released from an emergency department. 1  Among children ages 0 to 14 years, TBI results in an estimated:  2,685 deaths;  37,000 hospitalizations; and  435,000 emergency department visits annually. 1  The leading causes of TBI are:  Falls (28%);  Motor vehicle-traffic crashes (20%);  Struck by/against events (19%); and  Assaults (11%). 1  $60 Billion in costs to the US yearly

11   Shaw, Nigel. "The neurophysiology of concussion." Progress in Neurobiology 67.4 (2002): 281-344. Print.  skull.jpg skull.jpg  ever_concussion.jpg ever_concussion.jpg

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