1. PROCELL’s Transdermal Cosmeceuticals : pII SKIN™
Oct
I really appreciate Sanofi, KAIST, and authorities related to this symposium
for the invitation to introduce ProCell’s proprietary and innovative DDS platform technology-MITT.
And I also thank Dr. Seungju Lee for the invitation to this symposium and professor for your kind introduction.

2. Brand Competitiveness of pII-SKIN™●
Brand Competitiveness of pII-SKIN™
Production of highly purified
materials
Efficacy and safety validated
Product safety is verified by
certified clinical test
institution 3 2 4 1
Worldwide IP application
and registration
Publication in peer-reviewed
top scientific journals
Global Partner
: co-development of
cosmeceutical active
ingredients and PCT
application
Collaboration with
global cosmetic giants and
partnership with domestic
- based cosmetic companies
Efficient transdermal
delivery of active ingredients
Maximizing efficacy through
skin cell activation
Diverse application of active
ingredients to cosmetics
Fusion with innovative biotechnology
Collaboration with outstanding Global partners
Innovativeness of ProCell’s
platform technology
Development of unique and high-performance active ingredients
Uniqueness and high
performance of cosmeceutical
active ingredients
Top quality and safety-guaranteed active ingredients
ProCell’s top notch
technology
Self supply of cosme-
ceutical active ingredients

3. ProCell’s Platform Technology : MITT
Basic Technology (MITT)
Cargo (active ingredients)
▷ Antibodies
▷ Recombinant Proteins
▷ Peptides
▷ siRNA or DNA
▷ Low MW chemicals
▷ Nanoparticles
MTD
Macromolecule Transduction Domain
MITT
Macromolecule Intracellular Transduction Technology

4. Skin and Skin Cell Permeable MTD
Delivery of MTD-conjugated FITC into artificial skins
Delivery of MTD-conjugated FITC into skin cells 3
Keratinocyte
Melanocyte
Fibroblast Cells

5. pII-SKIN pII SKIN™ The novel platform for Cosmetics Anti-aging●
pII SKIN™ The novel platform for Cosmetics
Anti-aging
Anti-wrinkle
Skin penetrating MTDs
Whitening
Growth Factors
Pure to Skin
Premium to Skin
Precious to Skin
pII-SKIN ●
Skin-lifting
Elasticity
siRNAs
Moisturization
Functional Peptides
Skin nourishment
Paraben free
Mineral oil free
Natural Materials

6. ProCell’s Platform Technology - MITT for Transdermal Delivery-
MTD enhances skin permeability of cosmeceutical ingredients
1st action
MTD efficiently delivers active ingredients into stratum corneum and dermis
2nd action
MTD maximizes efficacy of active ingredients by intercellular or intracellular delivery

7. Dermal Fibroblast Proliferation
MTD-EGF Effect on
Dermal Fibroblast Proliferation
Human Dermal Fibroblast (NHDF)
NHDF (Human)
NIH3T(Mouse)
control
0.1 ng/mL
1.0 ng/mL
Mouse Fibroblast (NIH3T3)

8. Skin Permeability of MTD-EGF
0.3%
0.01%
EGF MTD-EGF
HCT 116 cells express wild type p53
Anti-cancer activity of MTD conjugated non-stapled p53 peptide is high,
compared to that of stapled p53 peptide to the colon cancer cells.
In addition, MTD-peptide conjugate shows the activity of caspase3/7 in a
concentration-dependent manner, compared to that of stapled p53 peptide.
In Aspc-1 cells expressing mutant p53, they show weak anticancer activity.
Skin permeability of MTD-conjugated EGF is 30 times more
than that of EGF after 24 hour treatment on artificial skin. 4

9. Dermal Fibroblast Proliferation
MTD-FGF2 Effect on
Dermal Fibroblast Proliferation
Human Dermal Fibroblast (NHDF)
control
0.8 ng/mL
3.0 ng/mL

10. Skin Permeability of MTD-FGF2
0.5%
0.25%
HCT 116 cells express wild type p53
Anti-cancer activity of MTD conjugated non-stapled p53 peptide is high,
compared to that of stapled p53 peptide to the colon cancer cells.
In addition, MTD-peptide conjugate shows the activity of caspase3/7 in a
concentration-dependent manner, compared to that of stapled p53 peptide.
In Aspc-1 cells expressing mutant p53, they show weak anticancer activity.
FGF2
MTD-FGF2
Skin permeability of MTD-conjugated FGF is 2 times more
than that of FGF after 24 hour treatment on cadaver skin. 4

11. Dermal Fibroblast Proliferation
MTD-FGF2 Effect on
Dermal Fibroblast Proliferation
Cell migration by MTD-FGF2
Human Dermal Fibroblast (NHDF)
control
5 ng/mL
MTD-FGF2 treatment greatly enhanced the migration of HUVEC cell compared to control.
control
1 ng/mL
3.0 ng/mL
Cell proliferation was stimulated in human dermal fibroblast after 72 hrs treatment of MTD-FGFs.

12. HUVEC Cell Proliferation and Migration
MTD-VEGF Effect on
HUVEC Cell Proliferation and Migration
Cell migration by MTD-VEGF
HUVEC cell
control
25 ng/mL 3 6 12 25
control
5 ng/mL
25 ng/mL
MTD-VEGF treatment greatly enhanced the migration of HUVEC cell compared to control.
Increased cell proliferation of HUVEC cells was observed after 72 hrs treatment of MTD-VEGF.

13. Skin Permeability & Collagen synthesis
Efficacy of acetylpentapeptide-MTD
Cadaver skin permeability of
acetylpentapeptide-MTD
In vitro collagen synthesis efficacy
of acetylpentapeptide-MTD
MTD-AP
Conc. : 10 ppm
Cell-line : NHDF
HCT 116 cells express wild type p53
Anti-cancer activity of MTD conjugated non-stapled p53 peptide is high,
compared to that of stapled p53 peptide to the colon cancer cells.
In addition, MTD-peptide conjugate shows the activity of caspase3/7 in a
concentration-dependent manner, compared to that of stapled p53 peptide.
In Aspc-1 cells expressing mutant p53, they show weak anticancer activity.

14. pII SKIN™ Solutions Products functions Characteristics
Regenerative Anti-wrinkle Cream
Anti-wrinkle
Advanced skin permeability of growth factors and peptides effective for skin elasticity : MEGF. MFGF, MVEGF, P2Skin-AP, P2Skin-AH
Exceptional efficacy of anti-wrinkle and skin elasticity, compared to any other brand’s products
Bright Whitening Serum
Whitening
New concept whitening ingredient by the collaboration with Institut Curie
IP co-application and registration in
International Cosmetic Ingredient Dictionary(ICID)
New concept whitening serum strengthened with anti-wrinkle and skin elasticity
Multi-factors Double Action
High-performance
- skin regeneration
- anti-aging
- anti-wrinkle
- whitening
Development of high-performance ampule containing highly purified and concentrated ingredients
Outstanding efficacy of anti-wrinkle and elasticity via customized ampule application
Strengthened skin regeneration and elasticity with the simultaneous use of anti-wrinkle cream 5

15. The main ingredients of pII-SKIN™ solutions●
The main ingredients of pII-SKIN™ solutions
Skin penetrating
MTDs
Skin penetration
Intracellular delivery
ProCell patented MTDs
M085, M1067, M2173A etc.
Growth Factors
Anti-aging/wrinkle
Hair regrowth
EGF, FGF-2, KFG, VEGF,
IGF-1, SCF, PDGD etc.
Functional proteins
Hormones
Anti-oxidation
Slimming
SOD, Irisin, FGF21 etc.
Functional Peptides
Anti-wrinkle
Whitening
Acetyl & Amidated
Di, Tri, Penta-peptides
Natural Materials
Moisturization
Skin nourishment
Plant extracts
Natural origin proteins

16. PROCELL Anti-wrinkle Cream ProCell Regenerative Anti-wrinkle Cream
PROCELL Regenerative Anti-wrinkle Cream contains ProCell’s platform technology-applied human growth factors such as
EGF, FGF, and VEGF designed for efficient transdermal delivery and high-performance peptides for anti-wrinkle, and
efficient delivery of these active ingredients into skin fibroblast cells helps skin regeneration and lifting.
ProCell Regenerative Anti-wrinkle Cream
Application
Anti-wrinkle, skin cell regeneration, and anti-aging
Main
Ingredients
Anti-wrinkle cream developed using innovative
human growth factors including EGF, FGF, VEGF
effective for anti-wrinkle and cell regeneration
MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF, MTD-VEGF, and other growth factors
MTD-applied skin permeable cell regenerative peptides
- MTD-conjugated peptides
Characteristics
EGF(Epidermal Growth Factor): interacts with skin cell receptors
and boosts proliferation of dermal fibroblast cells, and has
function of skin regeneration, anti-aging, and anti-wrinkle
In cancer cells, as p53 is degraded by ubiquitination of MDM2, it cannot inhibit the cell proliferation.
If MTD conjugated peptide or stapled peptide which inhibits the binding between p53 and MDM2
is delivered into cancer cells, the degradation of p53 is prevented .
The right panel of the slide shows the three dimensional structure of two kinds of MTD conjugated peptides
and one stapled peptide.
They are effectively transduced into the target cells.
FGF(Fibroblast Growth Factors) and VEGF(Vascular Endothelial
Growth Factor) induce proliferation and differentiation of
dermal fibroblast cells, and endotherial cells in blood vessel.
Both factors enhance the synthesis of collagen and elastin, finally
elevating skin elasticity.
ProCell Regenerative Anti-wrinkle Cream
Boosting the proliferation of dermal fibroblast
cells – anti-wrinkle effect
Enhanced skin elasticity through increased
collagen synthesis
- Reduction in transepidermal water loss(TEWL)
* Skin irritation and cytotoxicity test completed
Nonapeptide-29 Pentapeptide-4 and Nonapeptide-29 Hexapeptide-8: ProCell’s patented peptides highly effective for collagen synthesis and skin lifting. 6

17. PROCELL Skin Regenerative Ampule pII SKIN Multi-factors Double Action
pII SKIN Multi-factors Double Action System is developed by the aid of ProCell’s innovative platform technology designed
for efficient transdermal delivery of bioactive ingredients, and pII SKIN’s unique and optimized combination ratio of skin
permeable growth factors helps effective skin regeneration and lifting.
Application
Anti-wrinkle, collagen synthesis, and improved skin elasticity
Whitening and moisturization
pII SKIN Multi-factors Double Action
MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF2, MTD-VEGF
MTD-applied skin permeable cell regenerative peptides
- MTD-Acetylpentapeptide, MTD-Acetylhexapeptide
Niacinamide, Adenosine, Tranexamic acid
Main
Ingredients
pII SKIN Multi-factors Double Action contains
highly purified and concentrated skin-permeable
human growth factors effective for anti-aging and
anti-wrinkle. Also, pII SKIN Multi-factors Double Action helps skin regeneration via prompt and efficient delivery of human growth factors into skin
Ampule
- Concentration of growth factors, based on their optimized
combination ratio, and exceptional skin elasticity and
regeneration
- Anti-wrinkle and lifting effects on sagging skins
- Whitening via anti-oxidants and whitening ingredients
Regenerative Anti-wrinkle Cream
- Improved skin elasticity and regeneration, after application
of Ampule on deeply lined and sagging skins
- Skin protection by reduction of Transepidermal Water Loss
- Improved skin elasticity through collagen synthesis
Characteristics
In cancer cells, as p53 is degraded by ubiquitination of MDM2, it cannot inhibit the cell proliferation.
If MTD conjugated peptide or stapled peptide which inhibits the binding between p53 and MDM2
is delivered into cancer cells, the degradation of p53 is prevented .
The right panel of the slide shows the three dimensional structure of two kinds of MTD conjugated peptides
and one stapled peptide.
They are effectively transduced into the target cells.
pII SKIN Multi-factors Double Action
Boosting skin elasticity and regeneration
Anti-wrinkle and lifting effects on sagging skins
Whitening via anti-oxidants and whitening
ingredients
* Skin irritation and cytotoxicity test completed

18. PROCELL Whitening Serum
Whitening serum was developed by the application of ProCell’s innovation platform technology to Institut Curie’s new
concept whitening ingredient. Its main functions are inhibition of melanin translocation and melanogenesis, and
consequent reduction in melanin pigmentation
ProCell Bright Whitening Serum
ProCell Whitening Cream Serum Fresh
Application
Whitening, Anti-oxidant, and moisturizing
Main
Ingredients
Main ingredient of PROCELL WHITENING SERUM
Was developed by the application of ProCell’s
Innovative platform technology to Curie’s new
Concept whitening ingredient.
Co-development material with Institut Curie, France
- MTD-Kif13A
MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF, MTD-VEGF
Characteristics
Inhibitory effect of melanin translocation
Melanogenesis inhibition
Reduction in melanin pigmentation through the
deoxidation and removal of produced melanin
Boosting collagen synthesis
Strengthened moisturizing effect
Skin anti-aging effect using Omega ingredient rich in
vegetable oil and lycopene
PROCELL whitening Serum
Inhibitory effect of melanin translocation
In cancer cells, as p53 is degraded by ubiquitination of MDM2, it cannot inhibit the cell proliferation.
If MTD conjugated peptide or stapled peptide which inhibits the binding between p53 and MDM2
is delivered into cancer cells, the degradation of p53 is prevented .
The right panel of the slide shows the three dimensional structure of two kinds of MTD conjugated peptides
and one stapled peptide.
They are effectively transduced into the target cells.
Melanogenesis inhibition
Reduction in melanin pigmentation
through the deoxidation and inhibition
of melanin synthesis
Boosting collagen synthesis
Skin irritation and cytotoxicity test completed
Vol.: 30 mL 8

19. Thank you for your attention !
I introduced ProCell’s innovative platform technology, MITT, and its application.
It is true that innovative new drug development is very arduous and long process.
However, if the innovative technology such as MITT properly applied,
I think that the way of new drug development would be more convenient.
Thank you for your attention.
If you have any question, feel free to let me know.