Presentation on theme: "Tru Face Essence Ultra Ethocyn Tel-Aviv, Israel November, 9th 2011"— Presentation transcript:
1 Tru Face Essence Ultra Ethocyn Tel-Aviv, Israel November, 9th 2011
2 Ethocyn® Tru Face Essence Ultra RETURN TO FIRM A novel, proprietary ingredient specific to increasing the important elastin fiber production in skin.Chantal BurnisonBiochemistMedically and scientifically published inventorTru Face™ essence ULTRA
3 Tru Face™ essence ULTRA Chantal BurnisonBiochemistInventorAttorneyAreas of Study:Cell PhysiologistBiochemistryTru Face™ essence ULTRA
4 Tru Face™ essence ULTRA CV atFor detail of my CV and the many studies behind ETHOCYN in TFEU you can go to this Information website.Tru Face™ essence ULTRA4
5 Presentation Contents www.ethocyninfo.com Research and Development of Ethocyn MoleculeThe $20mm Safety and Efficacy Testing of EthocynResults of Medically Published Ethocyn Clinical TrialsEthocyn for Firmer, Smoother, More Beautiful Skin.This www, ethocyn.com information website will give you Information about Ethocyn. Of course, GO TO THE Nu SKIN website to purchase TFEU and learn about the other wonderful ingredients in TFEU.Tru Face™ essence ULTRA
6 Tru Face™ essence ULTRA How Ethocyn WorksUnique cosmetic ingredient in TFEU19 years and $20+ in research anddevelopment. A topical, safe andefficacious non steroidal anti-androgen.that penetrates to the dermiscausing fibroblast cell to make elastin at 20 year old youth levels.Research and development of Ethocyn moleculeTru Face™ essence ULTRA
7 Ethocyn World Testing Centers Works on:all skin ethnicitiesmale and female> than 25 years of ageTru Face™ essence ULTRA
8 Patents Issued/Pending Around the World Composition of matterProcessUseTrade SecretsIsomeric compositionStereo specific synthesisExo- and endo- ratio studiesIND (investigation of new drug) submissionsTrademarksEthocyn®Tru Face™ essence ULTRA
9 Ethocyn Scientific & Medical Publications Tru Face™ essence ULTRA9
10 Tru Face™ essence ULTRA The Ethocyn MoleculeOver $20 million and over 19 years of research and developmentSmall Mwt. 266, lipophilic moleculeNon-steroidal target tissue DHT-receptor blockerPassive diffusion to dermis (C14) transdermal penetration studiesSafe (44 studies; 5 species)Efficacious DHT receptor blocker (competitive inhibition)EthocynTru Face™ essence ULTRA
11 Ethocyn is Unique, Safe and Clinically Efficacious No other cosmetic ingredient in the world treats skin aging (skin laxity and wrinkling) in this important wayEthocyn is a proven safe and efficacious, small mwt. non steroidal anti androgenTFEU: Formulation that has optimally combined Ethocyn at its clinically proven MTD (maximum therapeutic dose) with extraordinary, moisturizers, antioxidants, mmp inhibitors, and collagen boosting ingredients.Ethocyn is a unique, patented firming ingredientEthocyn firms lax, wrinkled skin by increasing important skin elastin fibers contentElastin fibers are the skin’s “rubber bands”Tru Face™ essence ULTRA
12 Tru Face™ essence ULTRA It is important to have young skin levels of elastin fibersThe skin is comprised of collagen and elastin fibers.Collagen fibers are the structural fibers of the skin. They do not stretch well.Elastin fibers are the important “youth protein” fibers of skin. They give skin “snap back” elasticity.Young skin is abundant in elastin fibers. As we age elastin fiber content decreases.Remember: Our skin’s elastin fibers are what give skin its retraction and snap.It is elastin that gives young skin its firmness, smoothness, and resiliency.Tru Face™ essence ULTRA
14 Tru Face™ essence ULTRA Medical Text BookPeter T. Pugliese, M.D.School of Medicine at University of PennsylvaniaB’Nai Brith Americanism AwardMaison De Navarre Gold Medal AwardAmerican Academy of Dermatology memberAuthored >60 scientific papersGiven >100 scientific mtg. presentationsContributed >10 chapters to scientific textsPublished 4 booksTru Face™ essence ULTRA
15 Physiology of Skin Sagging and Wrinkles The wrinkle starts in the dermis as a decrease in the quantity and quality of elastin production by fibroblastCells which decrease in fiber causes the skin elastin fibers to lose their snap, and thus the skin becomes lax and loose. The skin sags.The skin is no longer able to retract to its original “young firm” state. As a result, sagging and crinkling occur in a pattern that is called wrinkles.Ethocyn increases important skin elastin fiber quantity and quality to that of young, 20 year old skin elastin quantity and quality. This has been proven (p<0.001) in controlled, punch biopsy Ethocyn clinical trials at major university medical centers.Tru Face™ essence ULTRA
16 The Single Most Important Cause…. “The single most important cause of age related wrinkles is the loss of skin elastin fibers, Everyone, whether female or male will begin to lose skin elastin fibers at age 25.Elastin fibers are the restorative force on the skin.”Peter T. Pugliese M.D.Internationally acclaimed author of the dermatology textbooks:Physiology of Skin II andAdvanced Professional Skin CareTru Face™ essence ULTRA
17 Only One Product in the World Can…. “Only one product in the world can restore your elastin level to that of 20 year old skin: Ethocyn.”Peter T. Pugliese M.D.Internationally acclaimed author of the dermatology textbooks:Physiology of Skin II andAdvanced Professional Skin CareTru Face™ essence ULTRA
18 Important Elastin Fibers and Skin Aging Elastin levels decreaseSkin loses contour and firmnessSkin sagsTru Face™ essence ULTRA
19 Ethocyn and Its Mechanism of Action Blocks what causes fibroblasts skin cells to stop producing elastin–the important youth-rendering skin’s rubber bands–that we have when we are young.Tru Face™ essence ULTRA
20 Intrinsic Aging and Loss of Skin Elastin Fibers Both men and women are born with DHT receptors in their fibroblast cellsWe are genetically predisposed to inheriting the amount, or quantity, of DHT receptors that we possessAfter years of age, no matter what our genetic make-up, we will have more DHT receptors than anti-androgens. We need to use topical Ethocyn 2x per dayTru Face™ essence ULTRA
21 An Androgen Enters the Skin Fibroblast cell Testosterone in males and Androsteindionein females are converted to DHT intracellularlyDHT inside the skin cells binds to the DHT receptorBound DHT-DHT receptor complex translocates to the nucleusWhen bound complex hits the nucleus, this signals the nucleus to stop producing elastinTru Face™ essence ULTRA
22 Ethocyn Topical Application and Proven Penetration The Ethocyn molecule penetrates skin dermis:Organically synthesized, non-steroidal antiandrogenHas a molecular weight of 266Penetrates through the stratum corneum to the dermis and enters the skin fibroblast cells which are the manufacturing sites for elastin productionTru Face™ essence ULTRA
23 DHT Receptor-DHT Androgen’ Fibroblast Cell Physiology: Circulating Testosterone (T) in males and Androsteindione (A) in females passively defuses into fibroblast cellsT and A converted to DHT via 5 alpha reductase enzymeDHT binds to the DHT receptorBound complex translocates to the nucleusWhen bound complex hits nuclear membrane: signals nucleus to decrease/ stop producing elastin proteinEthocyn has an affinity for the DHT receptorCompetitvely blocks the DHT from binding to its receptorAllows for more elastin to be producedTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
24 Ethocyn Clinical Trials Deliver at p<0.001 What can one expect to experience and see using Ethocyn?U.C.L.A.University of ShanghaiDermatologist Trials WorldwidePlastic Surgeon Trials alone; andin combination with Fraxel LaserTru Face™ essence ULTRA
25 Research and Publications Over $20 million and 19 years have been expended on Ethocyn research and development to date.Ethocyn is a unique, patented, clear and odorless oil concentrate invented by biochemist Chantal Burnison.Research aided by advanced cell-receptor laboratories, radioisotopes, and computer software.Ethocyn research and production laboratoryTru Face™ essence ULTRA
27 U.C.L.A. and Other University Ethocyn Clinical Trials Very objective Clinical Trials’ endpoints; evaluation objective (p<0.001)Precise quantitative assessment of skin elastin fiber content of subjects before and after the topical use of EthocynClinical Protocols were reviewed and approved by the United States FDATru Face™ essence ULTRATru Face™ essence ULTRA
28 UCLA Dept. of Dermatology Clinical Trials “Only Ethocyn can give your skin the elastin fiber content of 20 year old skin”Clinical TrialsConducted by Dr. Richard Strick, M.D. Clinical Professor of Dermatology at U.C.L.A.Protocols reviewed and approved by USA FDAPresented Ethocyn Clinical Trials’ research at the American Academy of Dermatology Medical Conference and several other medical forums.Dr. Richard Strick, M.D.Tru Face™ essence ULTRA
29 Tru Face™ essence ULTRA Ethocyn Clinical Efficacy University Medical Center’s Phase II Ethocyn Clinical2mm Punch biopsies --actual skin -- were taken from each subject ; slides randomized-thereby hiding identity of Subjects and time sequence.Quantitative computer image analysis of biopsies were conducted at Baseline, 1,2,3,4 and 6 months to assure accuracy and statistically significant results (p<0.001)Biopsy analyses: 250+ patients, male and female; yrs of age; different ethnicities.Tru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
30 Tru Face™ essence ULTRA Bioquant: Ethocyn Verhoeff Stained Clinical Biopsy AnalysesNathanael Reveal, PresidentDetailed Protocol5 micron Verhoff-Van Giesen (VVG) stained sections for formalin fixed, paraffin embedded full depth skin punch biopsies were analyzed by standardized, semi-automated image analysis to determine elastin content ratios.A trained technician, familiar with skin tissue morphology, used a software-assisted drawing tool to define a sampling area of the dermal layer a constant distance away from the epidermal layer and containing as much of the dermal layer of the skin visible with a 4X objective. The size of this sampling area, in square microns was recorded by the system.Elastin fiber content was measured within the sampling area using a 20X objective. Elastin fibers stain black with the VVG stain. Standardized image analysis was used to detect all black fibers within the sampling area. Automatic size filters excluded stained areas which were either too large or too small to be elastin fibers. Additional image analysis filters ensured that no fiber was measured more than once, even if measurements were made in adjacent, overlapping fields of view. Finally, technicians were able to manually exclude staining that was determined by observation not to be specific for elastin.All biopsies were measured twice independently by two different technicians. When possible, three serial sections were cut from each biopsy and the best quality section was analyzed. Biopsies for which sections were of poor quality or below a reasonable minimum size were excluded. Biopsies for which the data collected by both technicians did not agree within 10%, were also excluded.Data including sampling area, elastin area, and elastin to sampling area ratio were exported to Excel for subsequent analysis. Comparisons were made via students t-test with an alpha of 0.05.Pictures are attached. The include:Two consecutive sections from the same biopsy imaged with a 4X objective.Screenshot of the BIOQUANT software inspecting a biopsy section. Screen shot shows raw sampling area and elastin data, the boundary and elastin measurements on the section.A sample paraffin block containing a biopsy.The leica microtome used to cut sections from the paraffin block.An street corner photograph of the research office block where we have our lab operations. It's not much to look it. It's one lab in a very large building of labs.A photograph of a typical BIOQUANT workstation. A skin biopsy is displayed on the screen of the workstation.The imaging system used to collect images of the sections. This is an inverted automated scanning microscope. The blue and white box with the joystick is the movement controller. The black and white tube sticking out the right above the joystick is the digital camera.The last image is the imaging tray. It allows us to orient the section so that the epidermis is always up, regardless of how the section may be mounted on the slide.Biography of BIOQUANTBIOQUANT Image Analysis Corporation was founded in 2001 to develop analytical systems and services for lifescience research. BIOQUANT systems collect the data to quantitative describe the tissues of every organ in the body from the skin to the retina to bone.Research services provided by BIOQUANT allow sponsoring companies to access the analytical capacities of BIOQUANT's systems without the need to establish their own research facilities. Through a consultative process which may include experts from BIOQUANT's large network of partnering scientists, clients are assured of comprehensive and rigorous research services.BIOQUANT is on the cutting edge of digital pathology services, having recently introduced a modularized, yet fully automated microscopy imaging platform. This platform retains the flexibility of a traditional microscopy system that is needed to adapt to novel research projects while enabling high-throughput sub-micron slide scanning. This gives sponsoring organizations access to all of their data from any internet connected computer.Tru Face™ essence ULTRA
32 Tru Face™ essence ULTRA Double blind, punch biopsies conducted on hundreds of Subjects (25-77 years of age) at independent university medical centers confirm (p <0.001) Ethocyn increases your skin’s important elastin fiber content to the youthful levels of 20 year old individuals. Study’ Control Group year olds.Tru Face™ essence ULTRA
33 Ethocyn Clinical Trials’ Safety Evaluations Hematology:White Blood CellsHemoglobinBlood Platelet CountRed Blood CellsUrinalysis:ProteinOthersSerum Chemistry:SGPTSGOTTotal ProteinCholestrolCreatininePotassiumSodiumBUNAlkalinePhosphataseTrigluderidesTotal Bilirubin Hormone Assay:Total and Free Testosterone (TT and FT)Leutinizing Stimulating Hormone (LH)Follicle Stimulating Hormone (FSH)Estradiol.Synopsis and Conclusion: For all Subjects in all Ethocyn Clinical Trial Studies: All laboratory results both in Baseline and Final Visit were normal. During the analysis of the lab records, no significant change between Before Treatment and After Treatment was found. This was in line with the Ethocyn C14 Clinical Trial that confirmed its 100% metabolism in the skin by beta oxidation such that there is no parent Ethocyn compound entering systemic circulation.Tru Face™ essence ULTRA
34 A Topical, Safe, and Efficacious Cosmetic Ingredient 100% conversion via β oxidation in dermis to non-AAOCH2H3OCH3OHOOOONon-AA1ºmetabolitehoursCONCLUSION: non-parent AA Ethocyn molecule never enters systemic circulation. Confirmed viapharmacokinetic profiles in 3 species including human C14 studies (Groningen, Holland)Tru Face™ essence ULTRA
35 U.C.L.A. Ethocyn Clinical Trial Results FDA protocols: Safety and Efficacy end-pointsSubjects: years of age; Males and Females6 month; 3 month StudiesBaseline elastin: 9.2% (mean) in Six Month Study;8.1% (mean) in Three Month StudyEnd elastin: 18.2% (mean) in Six Month UCLA Study;21.3% (mean) in Three Month UCLA StudyUCLA Control Group (18-25 years old) elastin: 15.6%P<0.001Tru Face™ essence ULTRA
37 Breaking the Code at U.C.L.A. Ethocyn Clinical Trials Topical BID application of Ethocyn™ by patients aged years of age restores elastin production to levels normally obtained in youth (ages 18-25). The mean level of elastic tissue in Ethocyn™ treated individuals increased by 100% (in some patients over 500%) (P<0.001). Every individual, male and female subject, had shown improvement and had smoother, tighter and less wrinkled skin.American Academy of Dermatology Medical Conference, San Francisco, CaliforniaRichard Strick, M.D.Diplomat of American Academy of DermatologyClinical Professor of Dermatology, U.C.L.A. School of MedicineTru Face™ essence ULTRA
38 Ethocyn Clinical Trials and Plastic Surgery Jeffrey D. Hoefflin, M.D., F.A.C.S, F.I.C.S.Fully trained General surgeon, plastic surgeonDual Board Certified SurgeonDiplomate, The American Board of Plastic SurgeryFellow, The American College of SurgeonsFellow, The International College of SurgeonsFellow, Bay Surgical SocietyMember, Los Angeles Society of Plastic SurgeonsTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
39 Tru Face™ essence ULTRA Fractionated Laser ResurfacingNext generation of ‘safe’ and efficient’ lasersLess downtime compared to traditional lasersCan be performed in office settingFive to seven day healing processIndications: pigment dyschromias, hyperpigmentation,melasma, all levels of rhytids.Tru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
40 Tru Face™ essence ULTRA Laser Resurfacing Study ProtocolsDr. Jeffrey Hoefflin M.D., F.A.C.S., FICS2009 Ethocyn and Laser Resurfacing StudyFraxel Fractionated CO2 – Full Face Laser Skin ResurfacingTopical BID application of Ethocyn®Patient age range (aged years) Mean elastic tissue level in treated individuals increased 100% (p<0.001).Every individual (male and female) showed improvement and had smoother, tighter and less wrinkled skin.Tru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
41 Dr. Hoefflin Ethocyn + Laser Study 8 weeks Clinical Trials’ Study; 20 Patients: Aged yrs.Ethocyn application BID on one side and placebo on other. Double Blind, Placebo ControlledLaser Procedure after 45 days of Ethocyn BID (2x per day) regimenInterrupt Ethocyn application 5 days (post surgically)Resume Ethocyn applicationPhysician and patients subject to analysisConclusion, Patients Using Ethocyn Remarked More Younger, Firmer Skin on Ethocyn Treated SideTru Face™ essence ULTRA
42 Tru Face™ essence ULTRA Ethocyn and Laser Resurfacing Patient ExampleTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
43 Tru Face™ essence ULTRA Ethocyn and Laser Resurfacing Patient ExampleTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
44 Tru Face™ essence ULTRA Ethocyn and Laser Resurfacing Patient ExampleTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
45 Tru Face™ essence ULTRA Ethocyn Optimizes Laser ResultsTopical BID application of Ethocyn®Patients (aged years) – elastin restored to youth levels (ages )Mean elastic tissue level in treated individuals increased 100% (p<0.001).Every individual (male and female) showed improvement and had smoother, tighter and less wrinkled skin.Tru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
46 Tru Face™ essence ULTRA Dr. Hoefflin Ethocyn + Laser Clinical Trial 20102mm Punch biopsies --actual skin-- were taken from each subjectQuantitative computer image analysis of biopsies were conducted to assure accuracy and statistically significant results (p<0.001)Tru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
47 Ethocyn Medical Conferences and Publications 2011-2012 American Society of Plastic & Reconstructive Surgery:Oct Volume Issue 4S - p 110doi: /01.prs a2American Society of Plastic Surgery- Poster;Sept 23-27, 2011 in Denver, Colorado.Qara Raymi Dermatology Conference,Lima, PeruAugust 26-29, 2011Tru Face™ essence ULTRA
48 Tru Face™ essence ULTRA Advantages of Topical Ethocyn Tru Face Essence UltraAll serums formulated at clinically efficacious dose( Dose Response Studies: 15%, 10%, 5%, 0.5%, 0.25%, %)Non-phototoxicHypoallergenicNon-irritatingNon-fragranceProprietary anti-inflammatory, collagen boosting ingredient formulation, with excellent mmp inhibitor ingredientsMulti-functional formulation simplifies your daily skin care regimenRead Slide as a Summary about TFEU in generalTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S.
49 Ethocyn Tru Face Essence Ultra Formulated with Superior Collagen Boosting & Elastin and Collagen Preservation IngredientsTru Face™ essence ULTRAJeffrey D. Hoefflin, M.D., F.A.C.S. - ETHOCYN
50 Ethocyn Tru Face Essence Ultra Formulated with Superior Antioxidants
51 How to Use Ethocyn and Tru Face Essence Ultra Ethocyn Application:Metabolizes in the body within 8 to 10 hours–thereforeit should be applied TWICE DAILY, morning and evening.Tru Face™ essence ULTRA
52 Ethocyn and Sun Exposure Non-Phototoxic – You CAN go in the sun without worrying about redness or swelling.Try to protect your skin from the sun because the sun causes elastin fibers in the skin to become hard and non-resilient; a condition known as elastosis.Tru Face™ essence ULTRA
53 Tru Face™ essence ULTRA EthocynIncreases your skin’s ‘Rubber Bands’ (elastin fibers) to that of 20 year old skin with Ethocyn containing Tru Face Essence Ultra serum for…Firmer…. Smoother… More Snap Back, Beautiful SkinTru Face™ essence ULTRA
54 Tru Face™ essence ULTRA Ethocyn Announements“A major breakthrough in the fightagainst skin aging.”-Dr. Bruce Hensel, Channel 4 NewsEthocyn’s importance previewed on USA television news stations when Dr. Richard Strick presented at AAD Medical Conference“Ethocyn gives skin the elastin fiber content of 20 year old skin.”–Dr. Richard StrickUCLA Dermatology ProfessorTru Face™ essence ULTRA
55 Numerous Television News Broadcasts Covering Ethocyn clinical trials’ medical conference publications“Studies show this product works differently fromothers, and experts say it does work”“The compound actuallyrestores elasticity to aging skin.”-KTLA (Channel 5) Television News Report-NBC (Channel 4) Television News Report“What’s in this little bottle couldturn back the hands of time”“The Fountain of Youth in a bottle”-KTLA (Channel 5) Television News Report-Hard Copy Investigative News ReportTru Face™ essence ULTRA
56 Tru Face™ essence ULTRA Medical Directors of U.S. University Dermatology Departments state: “Ethocyn is the most effective cosmetic product available.”Interview of Dr. Tina Alster, Clinical Professor of Dermatology at Georgetown University School of Medicine.Her patients include politicians, newscasters, models and lawyers.Dr. Alster said, “To treat and prevent my own eye skin-area wrinkles: I use a drop of Chantal Ethocyn Vial Serum every morning and evening around my eyes…I recommend Ethocyn to all my patients.”Tru Face™ essence ULTRA
57 Ethocyn Users’ Testimonials “Within two weeks I saw a big difference.”“The ethocyn changed my skin in a wayI’ve never seen before.”“I feel like ethocyn is actually repairing my skin.”“It’s the perfect little magic drop.”“The tightness in my skin came back,I think everybody should know aboutEthocyn.”“I feel younger, I feel like I look younger.”“The ethocyn essence vial’s areEasy to use and gave me great results.”Tru Face™ essence ULTRA
58 Ethocyn Users’ Testimonials “Next to being a baby, this is the bestmy skin has ever looked.”“The lines have disappeared, I’m not feelinguncomfortable any more.”More people happy with Ethocyn use. Their statements.“It really just feels good”“My lines have disappeared, the sagginess has lifted.”Tru Face™ essence ULTRA
59 Ethocyn Treatment Products Used everyday by men and women who care about skin health and beautyKaren Philips, a working American wife, decided to test Ethocyn herself by using the product on only half of her face, twice a day, for 120 days.The results of her “half face test” are seen in this picture.Tru Face™ essence ULTRA
60 Tru Face™ essence ULTRA A beautiful product to have beautiful… firmer…youth elastin levels… skin.Everyday. Twice a day.Tru Face™ essence ULTRA