1. Excretion WASTE PRODUCTS OF BODY FUNCTIONS ARE REMOVED BY THE KIDNEYS Why do animals need an excretory system? What parts make up the excretory system? How does a kidney work? What can be done if the system does not function?

2. Learning Outcomes know that the kidneys regulate the water content of the blood and remove waste products from the blood. recognise and label a given diagram of the human excretory system to show: kidneys, renal artery, renal vein, ureters, urethra, bladder.

3. Excretion Waste products made in our cells need to be removed or they would poison us. This is excretion. In the liver excess amino acids are broken down to make urea. The urea is taken from the liver to the kidneys, where it is excreted.

4. The diagram below shows the excretory organs in our body.

5. The Kidneys

6. Pupil Activity Colouring in sheet The Urinary System Colour in the diagram Answer the questions

7. The Kidney Kidneys help to maintain the internal environment by: - Filtering the blood Reabsorbing all the sugar Reabsorbing the dissolved ions needed by the body Reabsorbing as much water as the body needs Releasing urea, excess ions and excess water as urine

8. Learning Outcomes know that the waste, a solution containing urea and excess salts called urine, passes from the kidneys in the ureters to the bladder where it is stored before being passed out of the body. Interpret data about the level of substances present in urine and during passage through the kidney. observe gross structure of a section through a kidney recognise and label a given diagram of a section through a kidney to include: cortex, medulla, pelvis, ureter and position of nephrons

10. Pupil activity Biology Foundations pages 82 – 83 Cleaning blood and balancing water – your kidneys Answer questions 1 – 4, 7 Copy and complete the “what you need to remember” sentences

11. Pupil Activity – Kidney Dissection Watch the demonstration on dissecting a kidney. In groups – dissect a kidney – try to identify all areas labelled in the diagram – medulla, cortex, pyramid, pelvis, ureter. You must wear safety goggles and a lab coat, and wash hands with anti-septic handwash once finished.

12. Learning Outcomes recognise and label a given simplified diagram of a nephron and its associated blood supply to show: capillary knot, Bowman's capsule, tubule, collecting duct, capillary network. understand the process of filtration under pressure know that selective reabsorption of glucose, some salts, and much of the water takes place in the tubule.

13. The Nephron As the blood passes through the capillary knot it is filtered, small molecules, urea, glucose, salts and water, pass out the capillary into the nephron

14. The glucose, water and some of the salts are needed by the body and are reabsorbed back into the blood from the nephron. The urea and waste salts left are dissolved in water to form urine. It flows down the ureter to the bladder. The “cleaned” blood leaves the kidneys in the renal vein

16. Activity Complete the diagram handed out on the structure of the nephron

17. Pupil activity colour in the formation of urine sheet. Answer questions 1 – 9 TRY ANSWER ALL QUESTIONS – information needed should all be on the side of the sheet that you coloured in!! Do not write on the sheet – write out full sentences into your book!! You have 25 minutes to complete this activity

18. Learning Outcomes know that the kidneys regulate the water content of the blood by producing dilute urine if there is too much water in the blood or concentrated urine if there is a shortage of water in the blood.

19. ADH ADH is a hormone, which controls the amount of water reabsorbed from the nephron. ADH is produced by the pituitary gland in the brain.

20. Control of water content The effect of ADH on the kidney Normal blood water level Increase in water level Detected by the pituitary gland Less ADH released into the blood stream Less water reabsorbed by the nephron More dilute urine produced decrease in water level Detected by the pituitary gland more ADH released into the blood stream More water reabsorbed by the nephron Small amount of concentrated urine produced

21. Tinkle Testing Practical Lesson Aim: to analyse urine samples and to draw conclusions from the results

22. Urine Samples Forensic scientists and doctors can discover a lot about someone from their urine, including kidney disease, diabetes and drug abuse.

23. Urine sampling in sports Monitor hydration levels Test for doping

24. Urine Chart

25. Fluid loss has a negative effect on performance

26. Sweat loss varies between different sports

27. Progress Questions Define the term homeostasis. What is urea? Where is it made? What is ultrafiltration? Where does it occur? What is selective reabsorbtion? What are the differences in composition between blood entering and leaving the kidney? What is ADH? Where is it produced? What is it’s function?

28. Progress Questions - 2 What would be the effect on the volume and concentration of urine of drinking a lot of fluid on a cold day? Explain why the regulation of water content of the blood is an example of negative feedback! If a person has kidney failure, how can they be kept alive?

29. Pupil activity Extension Handout – the kidneys and urinary system Answer questions 1 – 7 Homework colour in the formation of urine sheet. Answer questions 1 - 9

30. Kidney Disease Treatment of kidney disease using kidney dialysis or kidney transplants!

31. Learning Outcomes know that kidney failure may be treated by a transplant or by a dialysis machine and compare the advantages and disadvantages of the use of these methods know that a diseased kidney may be replaced by a healthy one by transplant from a donor of a similar 'tissue type' to the recipient. The donor kidney may be rejected, attacked by the immune system, unless anti-rejection drugs are taken.

32. Learning Outcome understand that in a dialysis machine a person's blood flows between selectively permeable membranes.

33. Dialysis in the Kidney

34. Kidney Dialysis Dialysis removes substances from a solution by diffusion This principle is put to use in a kidney dialysis machine

35. Kidney Dialysis - machine

36. Kidney Dialysis machine In a dialysis machine a person's blood flows between selectively permeable membranes. It is important that useful substances in the blood, such as glucose and salts, are not lost. To prevent this the dialysis fluid contains the same concentration of these substances as blood plasma.

37. This ensures that only urea and excess salts and water diffuse into the dialysis fluid. This treatment has to be carried out at regular intervals

38. Transplants Vs Dialysis Advantages Normal lifestyle Dialysis machine available for others to use Dialysis machines expensive to buy and maintain Disadvantages Requires a suitable donor (tissue match) Operation is expensive Risk of rejection of transplanted kidney (use of immunosupressor drugs) Religious beliefs