1. Resveratrolo

5. Ligand Induces a Conformational Change in the LBD that Repositions helix 12 No LigandAgonist

6. NR Antagonists Alter the Position of Helix 12 No Ligand Agonist (ER) Antagonist (ER)

8. PHENOL OH >100,000 Compounds>100,000 Compounds classified according to basic skeletal structureclassified according to basic skeletal structure acidicacidic Participates in oxidation- reduction reactionsParticipates in oxidation- reduction reactions

9. Polyphenol content Total polyphenols Red grape, ave. 5500 mg/kg Red wine 700–4000 mg/L White grape, ave. 4000 mg/kg White wine 150-400 mg/L

10. Quercetin, catechin, resveratrol Vascular benefits Quercetin, catechin, resveratrol Inhibition of platelet aggregation Inhibition of platelet aggregation Inhibition of LDL oxidation (plaque) Inhibition of LDL oxidation (plaque) Vasodilation Inhibition of vasoconstriction (tannins)

11. Anti-carcinogenic properties Stilbenes inhibit cell proliferation Stilbenes inhibit cell proliferation Association with decreased colon cancer Association with decreased colon cancer Inhibition of non-melanoma skin cancer -resveratrol Inhibition of non-melanoma skin cancer -resveratrol Estrogenic effect-resveratrol +/- Estrogenic effect-resveratrol +/-

37. Resveratrolo